A cohort of 108 unreferred, randomly selected elementary school students, diagnosed in the first grade for presence or absence of attention deficit disorder (ADD) and its constituent symptoms of inattention and impulsivity, will be followed up in seventh and eighth grade. Psychopathological, neuropsychological, and electrophysiological measurements will be made at this time to determine: (a) the degree to which a first grade diagnosis of ADD is reliable or persistent until seventh and eighth grade; (b) what abnormalities persist -- in the above measurement domains -- from first grade symptoms of ADD; and (c) the differential role of first grade inattention and impulsivity in the prediction of seventh and eighth grade abnormalities. Parents of the above probands will be measured in the same domains, with the addition of regional cerebral blood flow measurements during mnestic and selective attention task performance. The parent data will be used: (a) for the definition of child-parent correlations in the symptoms and measured manifestations of ADD, leading to the formulation and test of genetic hypotheses; and (b) for cross-validation of neuropsychological, electrophysiological, and regional cerebral blood measurements within the parent sample.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH049400-02
Application #
3388765
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1992-05-01
Project End
1995-04-30
Budget Start
1993-06-01
Budget End
1994-04-30
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106