Schizophrenic patients have shown a reduction in the amplitude of the P30O brain event-related potential (ERP) to tones, which has been reported to be maximal over the left temporal region in some studies. Our preliminary study replicated this finding and found evidence of reduced left brain dominance for dichotic words, which was most marked in schizophrenic patients with positive symptoms. This project aims to determine the effect of cognitive task demands on P300 reduction and asymmetry in schizophrenia, and to examine the relation of abnormal P3OO and dichotic listening asymmetry to symptom features (i.e., thought disorder and auditory hallucinations), gender and familial transmission of schizophrenia. A more long range goal is to determine the potential value of brain ERPs as predictors of therapeutic response to a conventional neuroleptic or to clozapine. ERP task demands will be manipulated using verbal (nonsense syllable) and nonverbal (complex tone) stimuli in easy binaural """"""""oddball"""""""" tasks and in more difficult dichotic listening tasks. ERPs and behavioral responses will be recorded in 90 schizophrenic patients and 30 normal controls. Patients will be tested after a minimum 4 week drug-free period and again after 6 weeks of treatment with haloperidol. Treatment nonresponders who receive clozapine will be retested again after 6 weeks on this medication. In addition, ERPs of at least 30 of the schizophrenic patients in the unmedicated period and all normal controls will be measured during a continuous word recognition task, which is thought to reflect left medial temporal lobe function. Clinical ratings will be obtained on several scales including: Positive and Negative Syndrome Scale, Thought Disorder Index, and BPRS. ERP and behavioral measures in the auditory perception and memory tasks should yield converging evidence for evaluating hypotheses concerning the existence of left temporal lobe deficits in a subtype of schizophrenia with positive symptoms and distinctive response to neuroleptics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH050715-01A2
Application #
2250059
Study Section
Special Emphasis Panel (SRCM (01))
Project Start
1994-08-01
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Kayser, Jürgen; Tenke, Craig E; Gil, Roberto et al. (2010) ERP generator patterns in schizophrenia during tonal and phonetic oddball tasks: effects of response hand and silent count. Clin EEG Neurosci 41:184-95
Kayser, Jürgen; Tenke, Craig E; Kroppmann, Christopher J et al. (2010) Current source density (CSD) old/new effects during recognition memory for words and faces in schizophrenia and in healthy adults. Int J Psychophysiol 75:194-210
Kayser, Jürgen; Tenke, Craig E; Gil, Roberto B et al. (2009) Stimulus- and response-locked neuronal generator patterns of auditory and visual word recognition memory in schizophrenia. Int J Psychophysiol 73:186-206
Tenke, Craig E; Kayser, Jurgen; Shankman, Stewart A et al. (2008) Hemispatial PCA dissociates temporal from parietal ERP generator patterns: CSD components in healthy adults and depressed patients during a dichotic oddball task. Int J Psychophysiol 67:1-16
Kayser, Jurgen; Tenke, Craig E; Gates, Nathan A et al. (2007) Reference-independent ERP old/new effects of auditory and visual word recognition memory: Joint extraction of stimulus- and response-locked neuronal generator patterns. Psychophysiology 44:949-67
Kayser, Jurgen; Tenke, Craig E (2006) Principal components analysis of Laplacian waveforms as a generic method for identifying ERP generator patterns: I. Evaluation with auditory oddball tasks. Clin Neurophysiol 117:348-68
Kayser, Jurgen; Tenke, Craig E (2006) Principal components analysis of Laplacian waveforms as a generic method for identifying ERP generator patterns: II. Adequacy of low-density estimates. Clin Neurophysiol 117:369-80
Kayser, Jurgen; Tenke, Craig E; Gates, Nathan A et al. (2006) ERP/CSD indices of impaired verbal working memory subprocesses in schizophrenia. Psychophysiology 43:237-52
Bruder, Gerard E; Wexler, Bruce E; Sage, Mia M et al. (2004) Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophr Res 68:137-47
Friedman, M S; Bruder, G E; Nestor, P G et al. (2001) Perceptual asymmetries in schizophrenia: subtype differences in left hemisphere dominance for dichotic fused words. Am J Psychiatry 158:1437-40

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