Do Glucocorticoids Exacerbate GP120 Neuroendangerment

Sapolsky, Robert M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Mental Health (NIMH)
• Type: Research Project (R01)
• Project #: 1R01MH053814-01A2
• Application #: 2254064
• Study Section: AIDS and Related Research Study Section 7 (ARRG)
• Project Start: 1996-08-01
• Project End: 1999-04-30
• Budget Start: 1996-08-01
• Budget End: 1997-04-30
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Stanford University
• Department: Biology
• Type: Schools of Arts and Sciences
• DUNS #: 800771545
• City: Stanford
• State: CA
• Country: United States
• Zip Code: 94305

Publications

Munhoz, Carolina Demarchi; Sorrells, Shawn F; Caso, Javier R et al. (2010) Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner. J Neurosci 30:13690-8

Zemlyak, Ilona; Brooke, Sheila; Sapolsky, Robert (2005) Estrogenic protection against gp120 neurotoxicity: role of microglia. Brain Res 1046:130-6

Dinkel, Klaus; Dhabhar, Firdaus S; Sapolsky, Robert M (2004) Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures. Proc Natl Acad Sci U S A 101:331-6

Brooke, Sheila M; Sapolsky, Robert M (2003) Effects of glucocorticoids in the gp120-induced inhibition of glutamate uptake in hippocampal cultures. Brain Res 972:137-41

Lim, Min Chin; Brooke, Sheila M; Sapolsky, Robert M (2003) gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120. Brain Res Bull 61:183-8

Dinkel, Klaus; MacPherson, Anna; Sapolsky, Robert M (2003) Novel glucocorticoid effects on acute inflammation in the CNS. J Neurochem 84:705-16

Dinkel, Klaus; Ogle, William O; Sapolsky, Robert M (2002) Glucocorticoids and central nervous system inflammation. J Neurovirol 8:513-28

Zemlyak, Ilona; Brooke, Sheila M; Sapolsky, Robert M (2002) Protection against gp120-induced neurotoxicity by an array of estrogenic steroids. Brain Res 958:272-6

Brooke, Sheila M; Sapolsky, Robert M (2002) Glucocorticoid exacerbation of gp120 neurotoxicity: role of microglia. Exp Neurol 177:151-8

Patel, Ravi; McIntosh, Laura; McLaughlin, John et al. (2002) Disruptive effects of glucocorticoids on glutathione peroxidase biochemistry in hippocampal cultures. J Neurochem 82:118-25