Fatigue is a highly prevalent and debilitating symptom of HIV-infection, associated with a high degree of psychological and functional morbidity. Recent reports estimate that fatigue is a distressing symptom in at least 40-50% of AIDS patients. During the course of conducting a study of the impact of pain on quality of life, we discovered that fatigue was among the most prevalent and distressing symptoms experienced by ambulatory AIDS patients, even more prevalent than pain. In our cohort of 360 AIDS patients, 72% experienced """"""""persistent fatigue (feeling tired all the time) for at least two weeks."""""""" Furthermore, our preliminary analyses demonstrate a significant association between fatigue and depression, hopelessness and overall psychological distress. Interventions for fatigue related to medical illnesses have included non-pharmacologic (exercise, energy conservation) and pharmacologic (corticosteroids, psychostimulants) therapies, however there have been few controlled studies. Psychostimulants have been demonstrated to be useful in the management of depressive symptoms, as well as, cognitive slowing (related to dementia) in cancer and AIDS patients. Thus, their potential as adjuncts to the management of fatigue is of interest to mental health professionals, particularly as it pertains to the interface between physical and psychological symptoms in the medically ill. Treatment of fatigue with psychostimulant medications (methylphenidate, amphetamine, pemoline) has been studied, to a limited degree, in cancer and multiple sclerosis, but has not yet been studied in HIV. This project's overall aim is to study the efficacy of psychostimulant drugs in the treatment of fatigue in HIV- infected patients. We will compare the frequency and severity of treatment emergent adverse side effects, as well as, examine the impact of psychostimulant treatment for fatigue on depression and overall quality of life. Specifically, we will be conducting a randomized, double-blind, placebo-controlled, parallel design trial, evaluating the relative benefits and risks of two psychostimulant medications (methylphenidate, pemoline), in the treatment of fatigue in HIV-infected patients. This study will be the first controlled evaluation of a pharmacologic intervention for fatigue in HIV-infected patients that utilizes novel psychotropic agents (psychostimulants), and assesses outcome with validated measures of fatigue (the Piper Fatigue Scale), side-effects, psychological distress and overall quality of life.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH054970-01A1
Application #
2255410
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1995-09-30
Budget End
1996-08-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Leuner, Benedetta; Gould, Elizabeth (2010) Structural plasticity and hippocampal function. Annu Rev Psychol 61:111-40, C1-3
Leuner, Benedetta; Glasper, Erica R; Gould, Elizabeth (2010) Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones. PLoS One 5:e11597
Leuner, Benedetta; Glasper, Erica R; Gould, Elizabeth (2010) Parenting and plasticity. Trends Neurosci 33:465-73
Leuner, Benedetta; Gould, Elizabeth (2010) Dendritic growth in medial prefrontal cortex and cognitive flexibility are enhanced during the postpartum period. J Neurosci 30:13499-503
Leuner, Benedetta; Glasper, Erica R; Gould, Elizabeth (2009) Thymidine analog methods for studies of adult neurogenesis are not equally sensitive. J Comp Neurol 517:123-33
Breitbart, W; Rosenfeld, B; Kaim, M et al. (2001) A randomized, double-blind, placebo-controlled trial of psychostimulants for the treatment of fatigue in ambulatory patients with human immunodeficiency virus disease. Arch Intern Med 161:411-20
Rosenfeld, B; Breitbart, W; Stein, K et al. (1999) Measuring desire for death among patients with HIV/AIDS: the schedule of attitudes toward hastened death. Am J Psychiatry 156:94-100
Breitbart, W; McDonald, M V; Rosenfeld, B et al. (1998) Fatigue in ambulatory AIDS patients. J Pain Symptom Manage 15:159-67