Blood oxygenation level dependent (BOLD) fMRI has generated an enormous amount of interest among neuroscientists, nuclear magnetic resonance scientists, and clinicians. It has rapidly become an important tool for studying neuronal activities in the human brain. However, despite various successful applications, the ability to detect task related changes by fMRI is potentially limited by signal fluctuations unrelated to the neuronal activation under investigation. In particular, it has been recognized that signal intensities in images are susceptible to physiological motions including respiration and cardiac pulsation. To improve the sensitivity of fMRI and to broaden its application, it is important to understand how the signals in fMRI vary with physiological motions and to develop means to compensate for these variations. Therefore, the overall goal of this project is to understand and reduce physiological fluctuations in fMRI and to demonstrate the improvement in fMRI with reduction of physiological fluctuation. Specifically, the proposed project will develop new methods for monitoring and compensating signal fluctuations related to respiration and cardiac pulsation in functional imaging data, validate the improvement with receiver operating characteristic analysis and reliability test, and assess and optimize various imaging sequences utilized for fMRI based on an objective assessment of signal contrast and physiological fluctuation using the techniques developed for physiological fluctuation monitoring. The improvement to be made in this project will be utilized to more sophisticated neuronal systems, including the olibocerebellar system, in the future.
| Van de Moortele, Pierre-Francois; Akgun, Can; Adriany, Gregor et al. (2005) B(1) destructive interferences and spatial phase patterns at 7 T with a head transceiver array coil. Magn Reson Med 54:1503-18 |
| Yacoub, Essa; Van De Moortele, Pierre-Francois; Shmuel, Amir et al. (2005) Signal and noise characteristics of Hahn SE and GE BOLD fMRI at 7 T in humans. Neuroimage 24:738-50 |
| Li, Zhi Hao; Sun, Xi Wen; Wang, Zhao Xin et al. (2004) Behavioral and functional MRI study of attention shift in human verbal working memory. Neuroimage 21:181-91 |
| Heberlein, Keith Arron; Hu, Xiaoping (2004) Simultaneous acquisition of gradient-echo and asymmetric spin-echo for single-shot z-shim: Z-SAGA. Magn Reson Med 51:212-6 |
| Wang, Danli; Heberlein, Keith; LaConte, Stephen et al. (2004) Inherent insensitivity to RF inhomogeneity in FLASH imaging. Magn Reson Med 52:927-31 |
| Pfeuffer, Josef; McCullough, Jeffrey C; Van de Moortele, Pierre Francois et al. (2003) Spatial dependence of the nonlinear BOLD response at short stimulus duration. Neuroimage 18:990-1000 |
| Yacoub, Essa; Duong, Timothy Q; Van De Moortele, Pierre-Francois et al. (2003) Spin-echo fMRI in humans using high spatial resolutions and high magnetic fields. Magn Reson Med 49:655-64 |
| Ma, Lin; Tang, Yiyuan; Wang, Yan et al. (2003) Mapping cortical areas associated with Chinese word processing using functional magnetic resonance imaging. Chin Med J (Engl) 116:176-80 |
| Atherton, Michael; Zhuang, Jiancheng; Bart, William M et al. (2003) A functional MRI study of high-level cognition. I. The game of chess. Brain Res Cogn Brain Res 16:26-31 |
| Zhang, Da Ren; Li, Zhi Hao; Chen, Xiang Chuan et al. (2003) Functional comparison of primacy, middle and recency retrieval in human auditory short-term memory: an event-related fMRI study. Brain Res Cogn Brain Res 16:91-8 |
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