The primary objective of this study is to evaluate the efficacy of a brief intervention designed to reduce high risk sexual practices of HIV+ individuals. This study was designed to enroll 400 HIV+ individuals over a five-year period, and was approved for 3 years. During the first 2-1/2 years, we have enrolled 200 subjects. Two additional years of funding will allow us to recruit and followup 200 more subjects so that sufficient data are available to test the efficacy of our intervention (N=400; 100/grp). Preliminary analyses indicate that our brief comprehensive intervention with boosters is effective in reducing high risk sexual practices of HIV+ individuals. Our intervention--TRIPLE """"""""S"""""""" (SHARE SAFER SEX)-- utilizes a randomized, pretest, multiple posttest, control group design. Our four group design addresses the question of how intensive (time and content) an intervention is necessary to achieve behavioral change. Four hundred sexually active HIV+ men and women are being randomly assigned to one of four conditions: (1) a brief (90 minute) one session targeted intervention focused on problem areas identified in three intervention domains (i.e., condom use, negotiation, disclosure); (2) a brief (90 minute) one session comprehensive intervention that covers all three intervention domains; 3) the same brief comprehensive intervention plus two monthly 90-minute booster sessions to reinforce behavior change; and (4) an attention-control condition (three 90-minute sessions) which addresses diet and exercise as related to HIV. Followup assessments are conducted at 4-, 8-, and 12-months post-intervention. The design of our intervention is guided by the principles of social cognitive theory. Skill-building exercises, demonstrations, role playing, rehearsal, and positive reinforcement are the main techniques used to enhance knowledge, self-efficacy, and positive outcome expectancies in the process of attaining desired behavioral change. A variety of behavioral outcomes are being examined (e.g., unprotected anal, vaginal, oral sex; partner types; number of HIV-partners). Moreover, subgroup differences in the effectiveness of the intervention based on gender, ethnicity, and key psychosocial factors (e.g., alcohol/drug use, stage of change) are being explored.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH056264-04
Application #
2874320
Study Section
Special Emphasis Panel (ZRG1-AARR-8 (01))
Program Officer
Weise, Richard E
Project Start
1996-08-01
Project End
2001-04-30
Budget Start
1999-06-01
Budget End
2000-04-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Semple, Shirley J; Grant, Igor; Patterson, Thomas L (2006) Perceived behavior of others and AIDS risk behavior among heterosexually-identified methamphetamine users. J Psychoactive Drugs Suppl 3:405-13
Semple, Shirley J; Patterson, Thomas L; Grant, Igor (2004) Determinants of condom use stage of change among heterosexually-identified methamphetamine users. AIDS Behav 8:391-400
Patterson, Thomas L; Shaw, William S; Semple, Shirley J (2003) Reducing the sexual risk behaviors of HIV+ individuals: outcome of a randomized controlled trial. Ann Behav Med 25:137-45
Semple, S J; Patterson, T L; Grant, I (2003) HIV-positive gay and bisexual men: predictors of unsafe sex. AIDS Care 15:3-15
Semple, Shirley J; Patterson, Thomas L; Grant, Igor (2003) Binge use of methamphetamine among HIV-positive men who have sex with men: pilot data and HIV prevention implications. AIDS Educ Prev 15:133-47
Patterson, Thomas L; Semple, Shirley J (2003) Sexual risk reduction among HIV-positive drug-using men who have sex with men. J Urban Health 80:iii77-87
Semple, Shirley J; Patterson, Thomas L; Grant, Igor (2002) Motivations associated with methamphetamine use among HIV+ men who have sex with men. J Subst Abuse Treat 22:149-56
Semple, S J; Patterson, T L; Grant, I (2000) The sexual negotiation behavior of HIV-positive gay and bisexual men. J Consult Clin Psychol 68:934-7
Semple, S J; Patterson, T L; Grant, I (2000) Psychosocial predictors of unprotected anal intercourse in a sample of HIV positive gay men who volunteer for a sexual risk reduction intervention. AIDS Educ Prev 12:416-30
Semple, S J; Patterson, T L; Grant, I (2000) Partner type and sexual risk behavior among HIV positive gay and bisexual men: social cognitive correlates. AIDS Educ Prev 12:340-56