This 5-year, two-site R0l proposal, based in New York and in Pittsburgh, is a competitive renewal of a high-risk study of the familial transmission of early-onset suicidal behavior. By the end of the first funding period, we will have recruited the offspring of two groups of probands-approximately 334 offspring of 167 mood disordered suicide attempters and a comparison group of 168 offspring of 83 mood disordered non-attempters. Probands, biological offspring over the age of 10, and the biological co-parent were characterized as to psychopathology, suicide attempt history, tendency to impulsive aggression and family environment, and were genotyped with polymorphic markers for serotonin pathway genes. Results of cross-sectional analyses indicate clear evidence of the familial transmission of suicidal acts and its relationship to both transmission of mood disorders and other psychopathology such as aggression/impulsivity and family adversity including sexual abuse. Offspring of multiplex families have the highest risk for attempt and earliest age of onset. We now propose to follow up offspring, as they move through the age of risk for a first suicide attempt. Probands will also be reassessed, as their clinical status can affect offspring outcome. Subjects will be re-assessed with respect to psychopathology, impulsive aggression, and suicidal behavior. In addition, laboratory-based measures of impulsivity and executive function, and more detailed assessment of trauma history and family adversity will be obtained. Direct sequencing of candidate genes will be conducted in families multiplex for suicide attempt. The prospective tracking of offspring will permit detection of the evolution of psychopathology and development of a predictive and explanatory model for the familial transmission of suicidal behavior. This study should lead to an empirical basis for the prevention and treatment of suicidal behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH056612-08
Application #
6767852
Study Section
Special Emphasis Panel (ZRG1-SNEM-2 (01))
Program Officer
Nottelmann, Editha
Project Start
1997-07-15
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
8
Fiscal Year
2004
Total Cost
$516,868
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Lawrence, Ryan E; Brent, David; Mann, J John et al. (2016) Religion as a Risk Factor for Suicide Attempt and Suicide Ideation Among Depressed Patients. J Nerv Ment Dis 204:845-850
Kerestes, Rebecca; Segreti, Anna Maria; Pan, Lisa A et al. (2016) Altered neural function to happy faces in adolescents with and at risk for depression. J Affect Disord 192:143-52
Keilp, John G; Stanley, Barbara H; Beers, Sue R et al. (2016) Further evidence of low baseline cortisol levels in suicide attempters. J Affect Disord 190:187-192
Turecki, Gustavo; Brent, David A (2016) Suicide and suicidal behaviour. Lancet 387:1227-39
Melhem, Nadine M; Keilp, John G; Porta, Giovanna et al. (2016) Blunted HPA Axis Activity in Suicide Attempters Compared to those at High Risk for Suicidal Behavior. Neuropsychopharmacology 41:1447-56
Pan, Lisa A; Ramos, Lisa; Segreti, AnnaMaria et al. (2015) Right superior temporal gyrus volume in adolescents with a history of suicide attempt. Br J Psychiatry 206:339-40
Dervic, K; Garcia-Amador, M; Sudol, K et al. (2015) Bipolar I and II versus unipolar depression: clinical differences and impulsivity/aggression traits. Eur Psychiatry 30:106-13
Brent, David A; Melhem, Nadine M; Oquendo, Maria et al. (2015) Familial pathways to early-onset suicide attempt: a 5.6-year prospective study. JAMA Psychiatry 72:160-8
Chin, Katherine H; Bell, Michael J; Wisniewski, Stephen R et al. (2015) Effect of administration of neuromuscular blocking agents in children with severe traumatic brain injury on acute complication rates and outcomes: a secondary analysis from a randomized, controlled trial of therapeutic hypothermia. Pediatr Crit Care Med 16:352-8
Brent, David A; Melhem, Nadine M; Mann, J John (2015) Pathways to offspring suicidal behavior may begin with maternal suicide attempt. J Am Acad Child Adolesc Psychiatry 54:868

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