Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH056890-07
Application #
6615614
Study Section
Special Emphasis Panel (ZRG1-MDCN-5 (01))
Program Officer
Winsky, Lois M
Project Start
1996-08-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
7
Fiscal Year
2003
Total Cost
$272,773
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Pinna, Graziano; Costa, Erminio; Guidotti, Alessandro (2009) SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol 9:24-30
Pinna, Graziano; Costa, Erminio; Guidotti, Alessandro (2006) Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) 186:362-72
Pinna, Graziano; Agis-Balboa, Roberto C; Zhubi, Adrian et al. (2006) Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc Natl Acad Sci U S A 103:4275-80
Rasmusson, Ann M; Pinna, Graziano; Paliwal, Prashni et al. (2006) Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry 60:704-13
Matsumoto, Kinzo; Pinna, Graziano; Puia, Giuli et al. (2005) Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress 8:85-93
Pinna, Graziano; Costa, Erminio; Guidotti, Alessandro (2005) Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior. Proc Natl Acad Sci U S A 102:2135-40
Pinna, Graziano; Costa, Erminio; Guidotti, Alessandro (2004) Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci U S A 101:6222-5
Pinna, Graziano; Agis-Balboa, Roberto C; Doueiri, Mohemed-Salim et al. (2004) Brain neurosteroids in gender-related aggression induced by social isolation. Crit Rev Neurobiol 16:75-82
Pinna, Graziano; Dong, Erbo; Matsumoto, Kinzo et al. (2003) In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci U S A 100:2035-40
Puia, G; Mienville, J-M; Matsumoto, K et al. (2003) On the putative physiological role of allopregnanolone on GABA(A) receptor function. Neuropharmacology 44:49-55

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