This study will establish whether sleep EEG dysregulation (low inter- and intrahemispheric coherence) is a reliable feature of childhood and adolescent depression, contrasting symptomatic and remitted children and adolescents with age- and gender-matched normal controls. The long range objective of identifying reliable biological features of depression is to improve on differential diagnosis, prognostication, and treatment selection. Of particular relevance to this application is the additional potential to identify patients prior to the clinical expression of the illness in order to ultimately intervene to prevent the onset of illness.
The specific aims are: 1) To establish which sleep EEG coherence measures are significantly lower in those with childhood depression (n=50) compared to age- and gender-matched health controls (n=50). 2) To establish which sleep EEG coherence measures are significantly lower in those with adolescent depression (n=50) compared to age- and gender-matched healthy controls (n=50). 3) To fully explore gender differences in sleep EEG coherence measures in the total sample of depressed (n=100) and control (n=100) and control (n=100) subjects. Equal numbers of males and females will be included in the total sample. We expect that gender differences will be evidence in adolescents with MDD. 4) To explore state-train characteristics of low-inter and intrahemispheric coherence in depressed children and adolescents. 5) A sub-aim is to evaluate the developmental time course of sleep EEG coherence in the 100 healthy controls as a means of determining how high inter- and intrahemispheric coherence measures are influenced by brain maturation. 6) To establish the relationship between sleep micro- and macro- architecture in childhood and adolescent MDD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH056953-01A2
Application #
2760415
Study Section
Special Emphasis Panel (ZMH1-CRB-H (05))
Program Officer
Nottelmann, Editha
Project Start
1999-06-15
Project End
2004-05-31
Budget Start
1999-06-15
Budget End
2000-05-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Wojnar, Julita; Brower, Kirk J; Dopp, Richard et al. (2010) Sleep and body mass index in depressed children and healthy controls. Sleep Med 11:295-301
Lopez, Jorge; Hoffmann, Robert; Armitage, Roseanne (2010) Reduced sleep spindle activity in early-onset and elevated risk for depression. J Am Acad Child Adolesc Psychiatry 49:934-43
Armitage, R (2007) Sleep and circadian rhythms in mood disorders. Acta Psychiatr Scand Suppl :104-15
Armitage, Roseanne; Hoffmann, Robert; Emslie, Graham et al. (2006) Sleep microarchitecture in childhood and adolescent depression: temporal coherence. Clin EEG Neurosci 37:1-9
Robert, Jennifer J T; Hoffmann, Robert F; Emslie, Graham J et al. (2006) Sex and age differences in sleep macroarchitecture in childhood and adolescent depression. Sleep 29:351-8
Armitage, Roseanne; Hoffmann, Robert; Emslie, Graham et al. (2004) Rest-activity cycles in childhood and adolescent depression. J Am Acad Child Adolesc Psychiatry 43:761-9
Shaffery, James; Hoffmann, Robert; Armitage, Roseanne (2003) The neurobiology of depression: perspectives from animal and human sleep studies. Neuroscientist 9:82-98
Armitage, Roseanne; Hoffmann, Robert F; Emslie, Graham J et al. (2002) Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression. Int J Neuropsychopharmacol 5:217-28
Emslie, G J; Armitage, R; Weinberg, W A et al. (2001) Sleep polysomnography as a predictor of recurrence in children and adolescents with major depressive disorder. Int J Neuropsychopharmacol 4:159-68