Given mounting evidence for prepubertal-specific manifestations of DSM- IV mania, establishing continuities/discontinuities of bipolarity (BP) across the lifespan is crucial. Because family studies are paramount among validating methodologies, the paucity of family study data from prepubertal BP probands is striking. An especially compelling opportunity to fill this gap in family study knowledge exists in our research unit because of ongoing phenomenologic, naturalistic course, and molecular genetic investigations. These ongoing studies are conducted on a population of 270 non-adopted probands aged 7-16 years old at baseline entry into the phenomenology project. These 270 subjects comprise 90 with BP (with or without ADHD), 90 with ADHD (without BP or other major mood disorders), and 90 community controls (without BP, other major mood disorders or ADHD) who were ascertained to optimize future family genetic studies. Thus, the family study proposed in this application will use an already established pediatric aged proband population and will include probands' first degree relatives, who already participate in molecular genetic investigations. In the proposed work, first degree relatives (mothers, fathers and siblings aged seven or older) will be directly assessed by blind raters to establish DSM-IV diagnoses. Data on deceased or otherwise unavailable relatives will be obtained by family history from two informants, to increase caseness. Incorporation of the proposed family study with ongoing interrelated and interlocking phenomenology, naturalistic course, and molecular-genetic investigations will provide crucial data on differentiating prepubertal BP from ADHD and on establishing continuities/discontinuities between prepubertal versus adult onset mania. This application is a second revision to NIMH R01 MH57451.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH057451-04S1
Application #
6742124
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Nottelmann, Editha
Project Start
1999-02-01
Project End
2004-08-06
Budget Start
2002-02-12
Budget End
2004-08-06
Support Year
4
Fiscal Year
2003
Total Cost
$63,051
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Tandon, Mini; Tillman, Rebecca; Agrawal, Arpana et al. (2016) Trajectories of ADHD severity over 10 years from childhood into adulthood. Atten Defic Hyperact Disord 8:121-30
Gallitano, Amelia L; Tillman, Rebecca; Dinu, Valentin et al. (2012) Family-based association study of early growth response gene 3 with child bipolar I disorder. J Affect Disord 138:387-96
Geller, Barbara; Harms, Michael P; Wang, Lei et al. (2009) Effects of age, sex, and independent life events on amygdala and nucleus accumbens volumes in child bipolar I disorder. Biol Psychiatry 65:432-7
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2008) Child bipolar I disorder: prospective continuity with adult bipolar I disorder;characteristics of second and third episodes;predictors of 8-year outcome. Arch Gen Psychiatry 65:1125-33
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2008) GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype. J Child Adolesc Psychopharmacol 18:25-9
Insel, Beverly J; Schaefer, Catherine A; McKeague, Ian W et al. (2008) Maternal iron deficiency and the risk of schizophrenia in offspring. Arch Gen Psychiatry 65:1136-44
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2006) Controlled, blindly rated, direct-interview family study of a prepubertal and early-adolescent bipolar I disorder phenotype: morbid risk, age at onset, and comorbidity. Arch Gen Psychiatry 63:1130-8
Tillman, Rebecca; Geller, Barbara (2006) Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors. Dev Psychopathol 18:1037-53
Geller, Barbara; Tillman, Rebecca; Badner, Judith A et al. (2005) Are the arginine vasopressin V1a receptor microsatellites related to hypersexuality in children with a prepubertal and early adolescent bipolar disorder phenotype? Bipolar Disord 7:610-6
Geller, Barbara; Tillman, Rebecca (2005) Prepubertal and early adolescent bipolar I disorder: review of diagnostic validation by Robins and Guze criteria. J Clin Psychiatry 66 Suppl 7:21-8

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