The proposed research will investigate the role of cognitive/social processing in maternal distress associated with pediatric bone marrow transplantation (BMT) in the treatment of pediatric cancer. Although heightened levels of distress among these mothers has been documented in clinical studies, little is known about the course of such distress during and after BMT or factors that place mothers at increased risk for adjustment problems. The research is guided by the integration of current models of cognitive/social processing. According to these models, the psychosocial impact of severe negative life events is related to how well the individual is able to integrate the event into his/her beliefs. This recovery process can be stifled when social constraints on talking about the event exist. In the proposed longitudinal analysis 509 mothers will be recruited to participate in a series of five structured interviews during the course of their child's BMT. Assessments of psychosocial and background factors will be conducted two weeks before BMT hospitalization, during the acute BMT hospitalization, and at 6, 12, and 18 months post-BMT.
Specific aims are to: 1) examine the course of psychological distress among mothers of children undergoing BMT; 2) determine the role of cognitive and social processing in the development and maintenance of mothers' psychological distress during and after their children's BMT; and 3) assess how dispositional optimism, monitoring coping style, and prior negative life events influence mothers' cognitive processing and development/maintenance of psychological distress. A combination of latent growth curve and structural equation modeling will be used in the data analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH057738-03
Application #
6165199
Study Section
Health Behavior and Prevention Review Committee (HBPR)
Program Officer
Muehrer, Peter R
Project Start
1998-05-01
Project End
2003-02-28
Budget Start
2000-03-01
Budget End
2001-02-28
Support Year
3
Fiscal Year
2000
Total Cost
$506,147
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
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Wu, Lisa; Bonanno, George; Duhamel, Katherine et al. (2008) Pre-bereavement meaning and post-bereavement distress in mothers of children who underwent haematopoietic stem cell transplantation. Br J Health Psychol 13:419-33
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Parsons, Susan K; Shih, Mei-Chiung; Duhamel, Katherine N et al. (2006) Maternal perspectives on children's health-related quality of life during the first year after pediatric hematopoietic stem cell transplant. J Pediatr Psychol 31:1100-15
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Manne, Sharon; DuHamel, Katherine; Ostroff, Jamie et al. (2004) Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation. Pediatrics 113:1700-8
DuHamel, Katherine N; Manne, Sharon; Nereo, Nancy et al. (2004) Cognitive processing among mothers of children undergoing bone marrow/stem cell transplantation. Psychosom Med 66:92-103
Rini, Christine; Manne, Sharon; DuHamel, Katherine N et al. (2004) Mothers' perceptions of benefit following pediatric stem cell transplantation: a longitudinal investigation of the roles of optimism, medical risk, and sociodemographic resources. Ann Behav Med 28:132-41
Manne, Sharon; Duhamel, Katherine; Ostroff, Jamie et al. (2003) Coping and the course of mother's depressive symptoms during and after pediatric bone marrow transplantation. J Am Acad Child Adolesc Psychiatry 42:1055-68

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