This project proposes to study biological and clinical correlates of functional recovery in bipolar subjects after an admission for mania. Specifically, we will explore whether neurocognitive, neuroanatomical or subsyndromal depression variables predict time to functional recovery or persistent functional impairment. We will 1) use a cross-sectional design to test specific hypotheses about factors that may discriminate between bipolar individuals who have concurrent functional recovery with symptomatic recovery versus those whose functional impairment persists after symptomatic recovery; 2) use a prospective design with multiple assessments over time in those patients who are functionally impaired at the time of symptomatic recovery to carefully track the temporal relationship (lag) between symptomatic recovery and functional recovery and test specific hypotheses about predictors of eventual functional recovery, and 3) contrast extreme outcome groups (i.e. those who have rapid functional recovery and those with markedly persistent residual impairment) to explore a hypothesis about brain structure and function in the two groups. An important feature of this study is that it will be done in the context of continuous, competent pharmacotherapy follow-up, thus reducing the potential for functional outcome to be confounded by suboptimal treatment and/or non-compliance. Identifying predictors of functional disability would be a first step toward understanding how and why functional impairment occurs; and would allow for appropriate rehabilitation/intervention strategies to be developed.
| Bearden, Carrie E; Shih, Vivian H; Green, Michael F et al. (2011) The impact of neurocognitive impairment on occupational recovery of clinically stable patients with bipolar disorder: a prospective study. Bipolar Disord 13:323-33 |
| Gitlin, Michael J; Mintz, Jim; Sokolski, Kenneth et al. (2011) Subsyndromal depressive symptoms after symptomatic recovery from mania are associated with delayed functional recovery. J Clin Psychiatry 72:692-7 |
| Yan-Meier, Leslie; Eberhart, Nicole K; Hammen, Constance L et al. (2011) Stressful life events predict delayed functional recovery following treatment for mania in bipolar disorder. Psychiatry Res 186:267-71 |
