Schizophrenia is associated with a fundamental deficit in selectivity that operates at all levels of information processing from basic sensory to higher order semantic processing. However the neurobiological bases of these deficits and their modulation through the course of the disease has not been established. We propose a series of studies that assess information selection deficits in schizophrenia within the framework of a multistage model, comprising an initial stage of sensory filtering or gating, a subsequent stage of sensory discrimination and memory processing, and a final stage of response selection. Parallel experiments will examine the functional and structural substrates of attention deficits in schizophrenia, using converging evidence from behavioral, electrophysiological (ERP) and functional Magnetic Resonance Imaging (fMRI) techniques. Electrophysiological (event-related potential, or ERP) studies will compare ERPs evoked in sensory gating, automatic and voluntary attention allocation, and response selection tasks in groups of schizophrenic patients and healthy controls. These studies will document ERP abnormalities at each level of processing previously observed in schizophrenic patients by the PI and her colleagues. Functional magnetic resonance imaging (functional MRI, or fMRI) studies will then be conducted using the same tasks and patterns of activation will be compared in healthy and schizophrenic subjects. Event-related fMRI analysis will be used to isolate activations evoked by task relevant and irrelevant stimuli. Group differences in activation patterns will be used to identify critical brain regions engaged at these levels of stimulus and response selection. The clinical objective of the proposed studies is to relate selective attention deficits in schizophrenia to symptomatology and chronicity of this illness. Information from these studies will further our understanding of the functional and structural basis of distractibility and information processing deficits in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH058251-05
Application #
6874512
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Program Officer
Meinecke, Douglas L
Project Start
2001-04-06
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2007-03-31
Support Year
5
Fiscal Year
2005
Total Cost
$224,140
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychiatry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
van Erp, Theo G M; Walton, Esther; Hibar, Derrek P et al. (2018) Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry 84:644-654
Andersen, Elizabeth H; Campbell, Alana M; Schipul, Sarah E et al. (2016) Electrophysiological Correlates of Aberrant Motivated Attention and Salience Processing in Unaffected Relatives of Schizophrenia Patients. Clin EEG Neurosci 47:11-23
Donkers, Franc C L; Englander, Zoƫ A; Tiesinga, Paul H E et al. (2013) Reduced delta power and synchrony and increased gamma power during the P3 time window in schizophrenia. Schizophr Res 150:266-8
Dougherty, Michael K; Gu, Hongbin; Bizzell, Joshua et al. (2012) Differences in subcortical structures in young adolescents at familial risk for schizophrenia: a preliminary study. Psychiatry Res 204:68-74
Belger, Aysenil; Carpenter, Kimberly L H; Yucel, Gunes H et al. (2011) The neural circuitry of autism. Neurotox Res 20:201-14
Carter, James D; Bizzell, Josh; Kim, Cy et al. (2010) Attention deficits in schizophrenia--preliminary evidence of dissociable transient and sustained deficits. Schizophr Res 122:104-12
Dichter, Gabriel S; Bellion, Carolyn; Casp, Michael et al. (2010) Impaired modulation of attention and emotion in schizophrenia. Schizophr Bull 36:595-606
Morey, Rajendra A; Mitchell, Teresa V; Inan, Seniha et al. (2008) Neural correlates of automatic and controlled auditory processing in schizophrenia. J Neuropsychiatry Clin Neurosci 20:419-30
Lewis, M M; Slagle, C G; Smith, A B et al. (2007) Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries. Neuroscience 147:224-35
van der Stelt, Odin; Lieberman, Jeffrey A; Belger, Aysenil (2006) Attentional modulation of early-stage visual processing in schizophrenia. Brain Res 1125:194-8

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