Studies outlined in this application propose to examine the relationship between the brain's ability to Inhibit incoming irrelevant sensory input (sensory gating and habituation) and (the absence of) phase resetting of the ongoing EEG. The relationship between the ability of the brain to respond to stimulus change (dishabituation) and phase resetting of the EEG will also be studied.
Our first aim i s to provide data supporting the hypothesis that phase resetting of the EEG (phase synchronization) plays an important role in determining the brain's response to novel stimuli. We also plan to show that the failure to phase reset the EEG plays a significant role in allowing the organism to stop responding (or inhibit the response) to repetitive irrelevant stimuli. Finally, we will demonstrate that both processes are deficient in schizophrenia patients. Utilizing a fuzzy logic technique and a single trial analysis method (both developed by this group) evoked potential data containing the P50 mid-latency auditory component will be compared between a group of schizophrenia patients and a group of age and sex matched normal controls. Data will be collected at the West Haven Veterans Hospital/Yale University and will be blindly analyzed in Dr. Jansen's laboratory at the Department of Computers and Electrical Engineering of the University of Houston. Data provided through this study will shed more light on the physiological mechanisms mediating the protective fundamental function of habituation. Elucidation of abnormalities of this function in schizophrenia patients will increase our understanding of this complex disorder and may contribute to developing more effective diagnostic instruments and therapeutic and rehabilitative interventions.
| Arfken, C L; Joseph, A; Sandhu, G R et al. (2014) The status of sleep abnormalities as a diagnostic test for major depressive disorder. J Affect Disord 156:36-45 |
| Jansen, Ben H; Hu, Lingli; Boutros, Nash N (2010) Auditory evoked potential variability in healthy and schizophrenia subjects. Clin Neurophysiol 121:1233-9 |
| Gjini, Klevest; Arfken, Cynthia; Boutros, Nash N (2010) Relationships between sensory ""gating out"" and sensory ""gating in"" of auditory evoked potentials in schizophrenia: a pilot study. Schizophr Res 121:139-45 |
| Lijffijt, Marijn; Moeller, F Gerard; Boutros, Nash N et al. (2009) Diminished P50, N100 and P200 auditory sensory gating in bipolar I disorder. Psychiatry Res 167:191-201 |
| Lijffijt, Marijn; Moeller, F Gerard; Boutros, Nash N et al. (2009) The Role of Age, Gender, Education, and Intelligence in P50, N100, and P200 Auditory Sensory Gating. J Psychophysiol 23:52-62 |
| Lijffijt, Marijn; Moeller, F Gerard; Boutros, Nash N et al. (2009) A pilot study revealing impaired P50 gating in antisocial personality disorder. J Neuropsychiatry Clin Neurosci 21:328-31 |
| Hu, Lingli; Boutros, Nash N; Jansen, Ben H (2009) Evoked potential variability. J Neurosci Methods 178:228-36 |
| Lijffijt, Marijn; Lane, Scott D; Meier, Stacey L et al. (2009) P50, N100, and P200 sensory gating: relationships with behavioral inhibition, attention, and working memory. Psychophysiology 46:1059-68 |
| Boutros, Nash N; Brockhaus-Dumke, Anke; Gjini, Klevest et al. (2009) Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients. Schizophr Res 113:339-46 |
| Wan, Li; Friedman, Bruce H; Boutros, Nash N et al. (2008) P50 sensory gating and attentional performance. Int J Psychophysiol 67:91-100 |
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