Sleep complaints are one of the most common health problems facing middle- and older-aged adults, resulting in significant medical utilization along with reduced psychological well-being and quality of life. In light of the cost and potential adverse effects accompanying long-term use of sedative-hypnotic medications, the development of alternative strategies for improving sleep in older populations is strongly indicated. One such potentially efficacious strategy is regular physical activity, a health behavior that typically diminishes with age. Although results from the first randomized, controlled trial evaluating the effects of increases in physical activity on sleep quality among healthy older adults with initial sleep complaints were promising, the study suffered from several methodological constraints that require further investigation. The objectives of this study are to: (1) determine the initial (6 months) and longer-term (12 months) effectiveness of a moderate-intensity physical activity program in promoting significant improvements in subjectively and objectively measured sleep quality in older adults with moderate sleep complaints; (2) evaluate the efficacy of the physical activity regimen for promoting initial and longer-term changes in a broad array of psychological and physical functioning (quality of life) variables; and (3) investigate a selected set of potential mediators and moderators of the physical activity/sleep relationship. The study design is a one-year randomized trial in which 120 sedentary women and men ages 55 years and older with moderate sleep complaints will be randomly assigned to one of two conditions: moderate-intensity physical activity training, or an attention-control (health education) condition. Both programs are designed to enhance long-term participation. Data will be collected at baseline and at 6 and 12 months using age-relevant physical performance and physical activity instruments, self-rated and objective sleep quality measures collected in the natural environment, and a comprehensive set of psychological and physical functioning scales. Our primary hypotheses are that subjects assigned to physical activity training will demonstrate significant increases in sleep quality along with other quality of life measures, maintained through 12 months, relative to the non-exercise control condition. This study will contribute important information with respect to the development of effective nonpharmacologic approaches to improving sleep quality among the large segment of healthy, community-dwelling older adults with sleep complaints.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH058853-04
Application #
6538855
Study Section
Mental Disorders of Aging Review Committee (MDA)
Program Officer
Muehrer, Peter R
Project Start
1999-08-15
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2002
Total Cost
$437,021
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Buman, Matthew P; Hekler, Eric B; Bliwise, Donald L et al. (2011) Exercise effects on night-to-night fluctuations in self-rated sleep among older adults with sleep complaints. J Sleep Res 20:28-37
Castro, Cynthia M; Lee, Kathryn A; Bliwise, Donald L et al. (2009) Sleep patterns and sleep-related factors between caregiving and non-caregiving women. Behav Sleep Med 7:164-79
King, Abby C; Pruitt, Leslie A; Woo, Sandra et al. (2008) Effects of moderate-intensity exercise on polysomnographic and subjective sleep quality in older adults with mild to moderate sleep complaints. J Gerontol A Biol Sci Med Sci 63:997-1004