The long-term goal is to develop novel analytical methods that will enable researchers to find sets of disease genes underlying complex traits. These methods make use of genetic linkage and linkage disequilibrium between markers and nearby disease genes and provide, for example, maximum likelihood estimates for the numbers and positions of disease genes. Results are expected to open the way to identifying susceptibility genes. Once such genes are found, there is hope that knowledge of their structure will lead to a deeper understanding of disease etiology and, thus, to the possibility of ameliorating or curing these traits. The three specific aims are 1) to apply the Ising model of statistical physics to linkage and disequilibrium analysis, 2) to investigate effects of pedigree errors on disequilibrium analysis, and 3) to implement methodology developed under this proposal in computer programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059492-02
Application #
6363728
Study Section
Mammalian Genetics Study Section (MGN)
Program Officer
Moldin, Steven Owen
Project Start
2000-03-01
Project End
2003-02-28
Budget Start
2001-03-01
Budget End
2002-02-28
Support Year
2
Fiscal Year
2001
Total Cost
$136,631
Indirect Cost
Name
Rockefeller University
Department
Biostatistics & Other Math Sci
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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Gordon, D; Levenstien, M A; Finch, S J et al. (2003) Errors and linkage disequilibrium interact multiplicatively when computing sample sizes for genetic case-control association studies. Pac Symp Biocomput :490-501
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Levenstien, Mark A; Yang, Yaning; Ott, Jurg (2003) Statistical significance for hierarchical clustering in genetic association and microarray expression studies. BMC Bioinformatics 4:62
Liu, Xin; Gordon, Derek (2003) A general class of association tests for family-based data using weight functions. Genet Epidemiol 24:208-19
Martinez-Mir, A; Zlotogorski, A; Londono, D et al. (2003) Identification of a locus for type I punctate palmoplantar keratoderma on chromosome 15q22-q24. J Med Genet 40:872-8

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