The thalamus is both a major relay station of sensory and perceptual information to the cortex as well as an important reciprocal participant in cortical action. These roles, both relevant to the sensory processing and executive action deficits in schizophrenia, make the thalamus a leading candidate structure for the defective link in the neural circuits involved in the disease diathesis. We begin with an existing sample of high resolution MR (1.2 mm spacing, SPGR) images of 76 normal controls (ages 20-90; 5 men, 5 women in each decade with oversampling of the 20-30 year group) and 42 unmedicated schizophrenic patients (including 10 never-medicated). We will add an additional older cohort of 32 patients to match the age and clinical course of an autopsy sample currently under study in another project and a younger cohort (n=24) of not previously medicated schizophrenic adolescents (age 13-18) and young adults (age 18-29). Lastly we will add 24 normal adolescents. This will yield a final population of 100 normals and 100 patients. We will examine 1) MRI anatomy of the major nuclear groups of the thalamus in a 100-person normal lifespan cohort and 100 patients with schizophrenia (ages 13-75); 2) white matter connections of the thalamus using diffusion tensor imaging to visualize direction and alignment of axon bundles and MRI morphometry to assess the internal capsule; and 3) volume of the gray and white matter of regions of the cortex reciprocally linked to the medial dorsal nucleus (prefrontal, cingulate, temporal regions). The medial dorsal and anterior regions are more closely connected with the frontal lobe and cingulate gyrus, while the pulvinar is more closely associated with temporal and occipital cortex. The data collected will illuminate relationships between volume loss in specific nuclei of the thalamus and cortical areas associated with these thalamic nuclei. The project brings the resources and the imaging/anatomical researchers of the Mount Sinai Department of Psychiatry, Neuroscience PET laboratory and the Department of Radiology together into a multidisciplinary and multimodal imaging consortium.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH060023-02
Application #
6186792
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Program Officer
Meinecke, Douglas L
Project Start
1999-08-01
Project End
2002-07-31
Budget Start
2000-08-30
Budget End
2001-07-31
Support Year
2
Fiscal Year
2000
Total Cost
$316,411
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
Mitelman, Serge A; Bralet, Marie-Cecile; Mehmet Haznedar, M et al. (2018) Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. Brain Imaging Behav 12:532-546
Balevich, Emily C; Haznedar, M Mehmet; Wang, Eugene et al. (2015) Corpus callosum size and diffusion tensor anisotropy in adolescents and adults with schizophrenia. Psychiatry Res 231:244-51
Lebedev, Artem; Miraghaie, Reza; Kotta, Kishore et al. (2013) Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer. Lab Chip 13:136-45
Zhang, Jing; Chu, King-Wai; Teague, Ella B et al. (2013) fMRI assessment of thalamocortical connectivity during attentional performance. Magn Reson Imaging 31:1112-8
Mitelman, Serge A; Canfield, Emily L; Brickman, Adam M et al. (2010) Progressive ventricular expansion in chronic poor-outcome schizophrenia. Cogn Behav Neurol 23:85-8
Segal, Devorah; Haznedar, M Mehmet; Hazlett, Erin A et al. (2010) Diffusion tensor anisotropy in the cingulate gyrus in schizophrenia. Neuroimage 50:357-65
Lehrer, Douglas S; Christian, Bradley T; Kirbas, Cemil et al. (2010) 18F-fallypride binding potential in patients with schizophrenia compared to healthy controls. Schizophr Res 122:43-52
Hazlett, Erin A; Byne, William; Brickman, Adam M et al. (2010) Effects of sex and normal aging on regional brain activation during verbal memory performance. Neurobiol Aging 31:826-38
Mitelman, Serge A; Canfield, Emily L; Chu, King-Wai et al. (2009) Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen. Schizophr Res 113:241-5
Schneiderman, Jason S; Buchsbaum, Monte S; Haznedar, M Mehmet et al. (2009) Age and diffusion tensor anisotropy in adolescent and adult patients with schizophrenia. Neuroimage 45:662-71

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