Abstract

The current proposal will focus on associative processes that depend on the basolateral amygdala (ABL). Second order conditioning and behaviors sensitive to reinforcement devaluation are markedly impaired by neurotoxic ABL lesions but unaffected by lesions of the amygdala central nucleus in rats. The proposed research will more fully characterize the ABL-dependent associations that underlay these behavioral functions and will investigate the neural circuitry that interconnects the ABL with prefrontal cortex and ventral striatum for its role in mediating these functions. The working hypothesis is that a CS's ability to acquire affective value, which serves as a basis for a CS's ability to serve as a secondary reinforcer, may be separable from a CS's ability to gain access to a representation of the US.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH060179-02
Application #
6186802
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (01))
Program Officer
Anderson, Kathleen C
Project Start
1999-08-05
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
2
Fiscal Year
2000
Total Cost
$247,133
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Johnson, Alexander W; Gallagher, Michela (2011) Greater effort boosts the affective taste properties of food. Proc Biol Sci 278:1450-6
Johnson, A W; Sherwood, A; Smith, D R et al. (2010) An analysis of licking microstructure in three strains of mice. Appetite 54:320-30
Petrovich, Gorica D; Ross, Cali A; Mody, Pari et al. (2009) Central, but not basolateral, amygdala is critical for control of feeding by aversive learned cues. J Neurosci 29:15205-12
Johnson, Alexander W; Gallagher, Michela; Holland, Peter C (2009) The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effects. J Neurosci 29:696-704
Saddoris, Michael P; Holland, Peter C; Gallagher, Michela (2009) Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortex. J Neurosci 29:15386-96
Jhou, Thomas C; Fields, Howard L; Baxter, Mark G et al. (2009) The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron 61:786-800
Furuyashiki, Tomoyuki; Holland, Peter C; Gallagher, Michela (2008) Rat orbitofrontal cortex separately encodes response and outcome information during performance of goal-directed behavior. J Neurosci 28:5127-38
Petrovich, Gorica D; Gallagher, Michela (2007) Control of food consumption by learned cues: a forebrain-hypothalamic network. Physiol Behav 91:397-403
Furuyashiki, Tomoyuki; Gallagher, Michela (2007) Neural encoding in the orbitofrontal cortex related to goal-directed behavior. Ann N Y Acad Sci 1121:193-215
Petrovich, Gorica D; Ross, Cali A; Gallagher, Michela et al. (2007) Learned contextual cue potentiates eating in rats. Physiol Behav 90:362-7

Showing the most recent 10 out of 27 publications