Abstract

Alterations in basic auditory perception in persons with schizophrenia have been noted for some time, but very little is known regarding how the changes in auditory behavioral function relate to underlying changes in anatomy and physiology. The relationship between poor auditory performance and the salient clinical symptoms of the disorder such as auditory hallucinations, if any, is also poorly understood. We are proposing an additional 5 years of funding to continue our efforts to characterize changes in the basic organizational principles of the auditory cortex in schizophrenia and their relationship to auditory psychophysics, clinical symptomatology and working memory. Magnetoencephalography (MEG), magnetic resonance imaging (MRI) and psychoacoustic methods will be employed to study these relationships in 80 people with schizophrenia and matched controls. We hypothesize that alterations in auditory physiology such as disturbed topographic mapping (i.e., tonotopy) and poorer frequency tuning underlie fundamental changes in auditory perceptual processes in schizophrenia. The impact of working memory and attention on perceptual and physiological changes in schizophrenia will also be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH060214-06
Application #
7057825
Study Section
Special Emphasis Panel (ZRG1-BDCN-B (01))
Program Officer
Meinecke, Douglas L
Project Start
1999-08-01
Project End
2009-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
6
Fiscal Year
2006
Total Cost
$270,686
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Wilson, Lisa B; Rojas, Donald C; Shatti, Shireen et al. (2013) Greater neuronal responses during automatic semantic processing in schizophrenia. Neuroreport 24:212-6
Davalos, Deana B; Rojas, Donald C; Tregellas, Jason R (2011) Temporal processing in schizophrenia: effects of task-difficulty on behavioral discrimination and neuronal responses. Schizophr Res 127:123-30
Reite, Martin; Reite, Erik; Collins, Dan et al. (2010) Brain size and brain/intracranial volume ratio in major mental illness. BMC Psychiatry 10:79
Rojas, Donald C; Slason, Erin; Teale, Peter D et al. (2007) Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia. Schizophr Res 97:206-14
Rojas, Donald C; Maharajh, Keeran; Teale, Peter D et al. (2006) Development of the 40Hz steady state auditory evoked magnetic field from ages 5 to 52. Clin Neurophysiol 117:110-7
Rojas, Donald C; Bawn, Susie D; Carlson, Jon P et al. (2002) Alterations in tonotopy and auditory cerebral asymmetry in schizophrenia. Biol Psychiatry 52:32-9