The following project is a supplement to the funded application """"""""ADHD Treatment: Comparative and Combined Dosage Effects (1 RO1 MH62946 01A1)."""""""" The parent grant funds an investigation of behavioral, stimulant, and combined treatment for ADHD. This supplement allows for the collection of normative information. Normalization of functioning has become an important yardstick in evaluating clinically meaningful and socially valid treatment results. By contrasting ADHD and comparison children we will be able to evaluate normalization effects of the three interventions in the parent grant-behavioral, stimulant, and combined treatments. We will also validate two measures of impairment within the context of the treatment study. No scale has been developed that is clinically useful and cost-effective for the regular repetitions required in measuring target outcomes in impairment and its reciprocal-adaptive functioning, We propose to evaluate in the context of the parent treatment study two measures of impairment for assessing treatment outcome: (1) the Impairment Rating Scale measures problems in daily life functioning and need for treatment as rated by parents, teachers, and clinicians across functional domains; and (2) the Functional Improvement Ratings (FIR) are domain specific clinical global impressionof improvement (CGI-I) in the child's functional impairments, competencies, and skills. The validity of these two ratings as indices of treatment effects will be investigated within the parent grant in which treatments will be manipulated and measured across multiple settings, domains, and sources. The following specific aims will be addressed: Do behavioral interventions, stimulant medication, and combinations of the two normalize functioning of ADHD children? Are cost effective measures of impairment sensitive to treatment effects (i.e., varying intensities and combinations of behavior modification and stimulant medication), and does sensitivity depend on the domain of impairment or the setting in which symptoms/ impairment is measured (e.g., recreational, classroom, and home settings) or individual differences (e.g., age)? Do measures of impairment offer unique variance in measuring treatment outcome above measures of DSM symptoms when normalized functioning is the gold standard?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH062946-02S1
Application #
6574173
Study Section
Special Emphasis Panel (ZMH1-ITV-D (01))
Program Officer
Wagner, Ann
Project Start
2001-07-15
Project End
2005-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2002
Total Cost
$25,990
Indirect Cost
Name
State University of New York at Buffalo
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
King, Kevin M; Pedersen, Sarah L; Louie, Kristine T et al. (2017) Between- and within-person associations between negative life events and alcohol outcomes in adolescents with ADHD. Psychol Addict Behav 31:699-711
Rhodes, Jessica D; Pelham, William E; Gnagy, Elizabeth M et al. (2016) Cigarette smoking and ADHD: An examination of prognostically relevant smoking behaviors among adolescents and young adults. Psychol Addict Behav 30:588-600
Wymbs, Frances A; Cunningham, Charles E; Chen, Yvonne et al. (2016) Examining Parents' Preferences for Group and Individual Parent Training for Children with ADHD Symptoms. J Clin Child Adolesc Psychol 45:614-631
Lu, Xi; Nahum-Shani, Inbal; Kasari, Connie et al. (2016) Comparing dynamic treatment regimes using repeated-measures outcomes: modeling considerations in SMART studies. Stat Med 35:1595-615
Rosch, Keri S; Fosco, Whitney D; Pelham Jr, William E et al. (2016) Reinforcement and Stimulant Medication Ameliorate Deficient Response Inhibition in Children with Attention-Deficit/Hyperactivity Disorder. J Abnorm Child Psychol 44:309-21
Pedersen, Sarah L; Walther, Christine A P; Harty, Seth C et al. (2016) The indirect effects of childhood attention deficit hyperactivity disorder on alcohol problems in adulthood through unique facets of impulsivity. Addiction 111:1582-9
Meinzer, Michael C; Pettit, Jeremy W; Waxmonsky, James G et al. (2016) Does Childhood Attention-Deficit/Hyperactivity Disorder (ADHD) Predict Levels of Depressive Symptoms during Emerging Adulthood? J Abnorm Child Psychol 44:787-97
Helseth, Sarah A; Waschbusch, Daniel A; Gnagy, Elizabeth M et al. (2015) Effects of behavioral and pharmacological therapies on peer reinforcement of deviancy in children with ADHD-only, ADHD and conduct problems, and controls. J Consult Clin Psychol 83:280-292
Molina, Brooke S G; Walther, Christine A P; Cheong, JeeWon et al. (2014) Heavy alcohol use in early adulthood as a function of childhood ADHD: developmentally specific mediation by social impairment and delinquency. Exp Clin Psychopharmacol 22:110-121
Molina, Brooke S G; Pelham Jr, William E (2014) Attention-deficit/hyperactivity disorder and risk of substance use disorder: developmental considerations, potential pathways, and opportunities for research. Annu Rev Clin Psychol 10:607-39

Showing the most recent 10 out of 31 publications