This application entitled: """"""""Emergence of Co-occurring Depressive and Externalizing Problems: Phenomenology, Course, and Outcome"""""""" was written as a response to RFA: MH-01-002. The Principal Investigator is a new investigator, who has convened a team of experienced developmental psychologists and research methodologists. Mental illness is a significant public health problem that is common in children and adversely affects their development. According to the recently published Surgeon General's Report, """"""""mental illnesses exact a staggering toll on millions of individuals, as well as on their families and communities, and our Nation as a whole."""""""" Critical to the Healthy People 2010 objective of reducing the prevalence of mental disorders among children and adolescents is a clearer understanding of the developmental processes underlying childhood psychopathology. For children who have mental disorders, co-occurrence of multiple disorders is more the rule than the exception. Yet very little is known about the differences in phenomenology, course, and outcome when disorders co-occur and when they do not. The proposed study is designed to identify developmental precursors, describe phenomenology, document developmental sequences, identify moderators and mediators of longitudinal course, and document functional outcomes in four groups of children. Study subjects will include children in three """"""""vulnerable"""""""" groups: depressive, only; externalizing, only; and co-occurring depressive and externalizing; and a comparison group of children without these vulnerabilities. The study will be conducted in King County, Washington. Study subjects will be selected on the basis of school problem status and parent-reported internalizing and externalizing problems from among 6th grade students in the Seattle Public Schools. In-person structured interviews focusing on key study constructs will be conducted with children and their caregivers and teachers at Baseline and at 12 and 24-month follow-up, with telephone/mail interviews conducted at intervening points. To address study aims, longitudinal data will be analyzed using logistic regression, Cox proportional hazards, growth mixture models, and classification and regression tree (CART) methods. Understanding the nature of co-occurring psychopathology will have important implications for nosology, as well as for the development of effective prevention and treatment approaches. The availability of a diverse population of children, the collaborative relationship between the University of Washington and the Seattle Public School District, and the experienced team of researchers create excellent conditions to conduct a study that can specifically address the questions posed in this RFA.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH063711-03S1
Application #
6837966
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Tuma, Farris K
Project Start
2001-09-16
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
3
Fiscal Year
2004
Total Cost
$95,726
Indirect Cost
Name
University of Washington
Department
Psychiatry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Adrian, Molly; Moreno, Megan; Nicodimos, Semret et al. (2018) Research strategy for health sciences: Facebook friend request is non-differentially accepted in a diverse, young adult population. Nurs Health Sci :
Rhew, Isaac C; Fleming, Charles B; Vander Stoep, Ann et al. (2017) Examination of cumulative effects of early adolescent depression on cannabis and alcohol use disorder in late adolescence in a community-based cohort. Addiction 112:1952-1960
Luk, Jeremy W; King, Kevin M; McCarty, Carolyn A et al. (2016) Measurement Invariance Testing of a Three-Factor Model of Parental Warmth, Psychological Control, and Knowledge across European and Asian/Pacific Islander American Youth. Asian Am J Psychol 7:97-107
Kim, JaHun; Chan, Ya-Fen; McCauley, Elizabeth et al. (2016) Parent-Child Discrepancies in Reporting of Child Depression in Ethnic Groups. J Nurse Pract 12:374-380
Adrian, Molly; Miller, Adam Bryant; McCauley, Elizabeth et al. (2016) Suicidal ideation in early to middle adolescence: sex-specific trajectories and predictors. J Child Psychol Psychiatry 57:645-53
Adrian, Molly; Kiff, Cara; Glazner, Chris et al. (2015) Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach. J Psychiatr Res 68:125-33
Adrian, Molly; McCarty, Carolyn; King, Kevin et al. (2014) The internalizing pathway to adolescent substance use disorders: mediation by ruminative reflection and ruminative brooding. J Adolesc 37:983-91
Wymbs, Brian T; McCarty, Carolyn A; Mason, W Alex et al. (2014) Early adolescent substance use as a risk factor for developing conduct disorder and depression symptoms. J Stud Alcohol Drugs 75:279-89
McCarty, Carolyn A; Wymbs, Brian T; Mason, W Alex et al. (2013) Early adolescent growth in depression and conduct problem symptoms as predictors of later substance use impairment. J Abnorm Child Psychol 41:1041-51
Kuo, Elena S; Vander Stoep, Ann; Herting, Jerald R et al. (2013) How to identify students for school-based depression intervention: can school record review be substituted for universal depression screening? J Child Adolesc Psychiatr Nurs 26:42-52

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