Abstract

The objective of this study is to examine the role of microvascular disease and neuroanatomical changes in the pathophysiology of depression in patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM, Type 2 Diabetes). Vascular factors and structural brain changes have been implicated in the etiology of mood disorders. However, the precise role of microvascular disease, its relationship to anatomical measures and the mechanisms and pathways that lead to depression remain largely unknown. NIDDM is a common metabolic disorder with microvascular compromise in several organs including the Central Nervous System. In addition, the prevalence of major depressive disorder (MDD) in patients with NTDDM is estimated to be approximately 15 percent. This combination renders NTDDM a powerful clinical model to concurrently study the role of structural brain measures and microvascular disease in mood disturbances. We will use magnetic resonance imaging (MRI) to obtain in vivo measures of neuroanatomy. Fundus photography will be used to obtain estimates of retinal microvascular disease, which is conceptualized as a marker of microvascular disease in the brain. We will integrate the biological and behavioral measures and elucidate their collective contributions to the pathophysiology of clinically significant depression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH063764-04
Application #
6891076
Study Section
Special Emphasis Panel (ZRG1-BDCN-5 (01))
Program Officer
Meinecke, Douglas L
Project Start
2002-05-01
Project End
2008-03-09
Budget Start
2005-05-25
Budget End
2008-03-09
Support Year
4
Fiscal Year
2005
Total Cost
$610,880
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Wu, Minjie; Kumar, Anand; Yang, Shaolin (2016) Development and aging of superficial white matter myelin from young adulthood to old age: Mapping by vertex-based surface statistics (VBSS). Hum Brain Mapp 37:1759-69
Kumar, A; Yang, S; Ajilore, O et al. (2016) Biophysical changes in subcortical nuclei: the impact of diabetes and major depression. Mol Psychiatry 21:531-6
Fang, Liang; Wu, Minjie; Ke, Hengyu et al. (2016) Adaptively optimized combination (AOC) of magnetic resonance spectroscopy data from phased array coils. Magn Reson Med 75:2235-44
Yang, Shaolin; Wu, Minjie; Ajilore, Olusola et al. (2016) Metabolic Aberrations Impact Biophysical Integrity of Macromolecular Protein Pools in the Default Mode Network. Diabetes 65:3464-3472
Yang, Shaolin; Ajilore, Olusola; Wu, Minjie et al. (2015) Impaired macromolecular protein pools in fronto-striato-thalamic circuits in type 2 diabetes revealed by magnetization transfer imaging. Diabetes 64:183-92
Ajilore, O; Lamar, M; Medina, J et al. (2015) Disassociation of verbal learning and hippocampal volume in type 2 diabetes and major depression. Int J Geriatr Psychiatry 30:393-9
Lamar, Melissa; Rubin, Leah H; Ajilore, Olusola et al. (2015) What Metabolic Syndrome Contributes to Brain Outcomes in African American & Caucasian Cohorts. Curr Alzheimer Res 12:640-7
Cohen, Jamie; Penney, Dana L; Davis, Randall et al. (2014) Digital Clock Drawing: differentiating ""thinking"" versus ""doing"" in younger and older adults with depression. J Int Neuropsychol Soc 20:920-8
Kumar, A; Yang, S; Ajilore, O et al. (2014) Subcortical biophysical abnormalities in patients with mood disorders. Mol Psychiatry 19:710-6
Lin, Meijin; Kumar, Anand; Yang, Shaolin (2014) Two-dimensional J-resolved LASER and semi-LASER spectroscopy of human brain. Magn Reson Med 71:911-20

Showing the most recent 10 out of 22 publications