Bulimic pathology is one of the most common psychiatric problems faced by adolescent girls, shows a persistent course, can result in serious medical complications, and is associated with psychiatric comorbidity and functional impairment. Although longitudinal studies have identified risk factors that increase the likelihood of bulimic pathology, these factors show modest predictive power and little is known about resource factors that decrease risk for bulimic pathology, protective and potentiating factors that mitigate or amplify the effects of risk factors, and how these factors """"""""work together"""""""" in a multivariate sense. There have also been few studies on maintenance factors that predict bulimic pathology persistence or the role of psychiatric comorbidity in the etiology and maintenance of this disorder. Further, past studies suffered from certain methodological limitations (e.g., small samples, short follow-up periods, high attrition, mono-reporter data, and sole reliance on survey data). The primary aims of this study are to examine putative risk and resource factors for bulimic pathology and the protective and potentiating factors that moderate these effects, and to test multivariate etiologic models. Secondary aims are to examine putative maintenance factors for bulimic pathology and the role of psychiatric comorbidity in the onset and persistence of this pathology. A tertiary aim is to further document the impact of bulimic pathology on subjective distress, functional impairment, and health care utilization.
Aims will be achieved by following a large representative cohort of girls ( N = 496), which has been assessed annually for 4 years since early adolescence (modal age = 13 at T1), for an additional 4 years. When complete, this cohort will have been followed annually for eight years, making it the longest prospective study of adolescent bulimic pathology to date. Key limitations of past studies will be addressed (e.g., by collecting multiple-reporter data and using structured interviews) and advanced quantitative methods will be utilized. Thus, the proposed continuation of this longitudinal study should advance our knowledge of the etiologic and maintenance processes for bulimic pathology and provide direction for the design of prevention and treatment programs for this serious psychiatric problem.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH064560-04S1
Application #
7124792
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Chavez, Mark
Project Start
2002-08-01
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
4
Fiscal Year
2005
Total Cost
$183,330
Indirect Cost
Name
University of Texas Austin
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
Val-Laillet, D; Aarts, E; Weber, B et al. (2015) Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. Neuroimage Clin 8:1-31
Burger, Kyle S; Stice, Eric (2014) Greater striatopallidal adaptive coding during cue-reward learning and food reward habituation predict future weight gain. Neuroimage 99:122-8
Stice, Eric; Burger, Kyle; Yokum, Sonja (2013) Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods. Neuroimage 67:322-30
Stice, Eric; Figlewicz, Dianne P; Gosnell, Blake A et al. (2013) The contribution of brain reward circuits to the obesity epidemic. Neurosci Biobehav Rev 37:2047-58
Yokum, S; Ng, J; Stice, E (2012) Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int J Obes (Lond) 36:656-64
Huh, David; Stice, Eric; Shaw, Heather et al. (2012) Female overweight and obesity in adolescence: developmental trends and ethnic differences in prevalence, incidence, and remission. J Youth Adolesc 41:76-85
Thomas, J Graham; Butryn, Meghan L; Stice, Eric et al. (2011) A prospective test of the relation between weight change and risk for bulimia nervosa. Int J Eat Disord 44:295-303
Gearhardt, Ashley N; Yokum, Sonja; Orr, Patrick T et al. (2011) Neural correlates of food addiction. Arch Gen Psychiatry 68:808-16
Burger, Kyle S; Stice, Eric (2011) Relation of dietary restraint scores to activation of reward-related brain regions in response to food intake, anticipated intake, and food pictures. Neuroimage 55:233-9
Yokum, Sonja; Ng, Janet; Stice, Eric (2011) Attentional bias to food images associated with elevated weight and future weight gain: an fMRI study. Obesity (Silver Spring) 19:1775-83

Showing the most recent 10 out of 37 publications