Major depressive disorder, disruptive behavior disorders, and anxiety disorders are all significantly associated with suicidal ideation and attempts in adolescents. Yet, the nature of the relation between psychopathology and suicidality has been greatly understudied. The purpose of this 3-year application is to test a cognitive mediational model to explain this relationship. Specifically, it is hypothesized that psychopathology is related to suicidality through unique dysfunctional cognitive processes and products linked with various clinical disorders in adolescents. The proposed study will also explore the manner in which comorbid forms of psychopathology affect dysfunctional cognitive processes and products, and suicidality in adolescents. It is hypothesized that depressed adolescents with comorbid psychopathology will exhibit more severe dysfunctional cognitive processes and products, and thus further increase their suicide risk. Secondarily, gender differences across mediational and comorbidity related findings would be explored. More complex competing models will also be tested. The proposed study will employ a cross-sectional design to test hypotheses. Two hundred and fifty psychiatrically hospitalized adolescents will be asked to complete a diagnostic interview and symptom inventories to assess psychopathology, as well as performance based measures and questionnaires to assess dysfunctional cognitive processes, cognitive products, and suicidality. Analyses will include the use of structural equation modeling (SEM) techniques, hierarchical regression analyses, and analyses of variance (ANOVA). Information obtained from this study will help explicate cognitive patterns in suicidal adolescents with varying forms of psychopathology and could ultimately be used to tailor cognitive-behavioral and multimode interventions for these high risk youth. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH065885-03
Application #
6999784
Study Section
Biobehavioral and Behavioral Processes 3 (BBBP)
Program Officer
Avenevoli, Shelli A
Project Start
2004-01-01
Project End
2007-12-31
Budget Start
2006-01-01
Budget End
2007-12-31
Support Year
3
Fiscal Year
2006
Total Cost
$145,807
Indirect Cost
Name
Brown University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Miller, Adam Bryant; Williams, Caitlin; Day, Catherine et al. (2017) Effects of Cognitive Distortions on the Link Between Dating Violence Exposure and Substance Problems in Clinically Hospitalized Youth. J Clin Psychol 73:733-744
Machell, Kyla A; Rallis, Bethany A; Esposito-Smythers, Christianne (2016) Family environment as a moderator of the association between anxiety and suicidal ideation. J Anxiety Disord 40:1-7
Mallard, Travis T; Doorley, James; Esposito-Smythers, Christianne L et al. (2016) Dopamine D4 receptor VNTR polymorphism associated with greater risk for substance abuse among adolescents with disruptive behavior disorders: Preliminary results. Am J Addict 25:56-61
Rizzo, Christie J; Esposito-Smythers, Christianne; Swenson, Lance et al. (2014) Dating violence victimization, dispositional aggression, and nonsuicidal self-injury among psychiatrically hospitalized male and female adolescents. Suicide Life Threat Behav 44:338-51
Wolff, Jennifer; Esposito-Smythers, Christianne; Becker, Sara et al. (2014) Social-Cognitive Moderators of the Relationship between Peer Victimization and Suicidal Ideation among Psychiatrically Hospitalized Adolescents. J Aggress Maltreat Trauma 23:268-285
Wolff, Jennifer C; Frazier, Elisabeth A; Esposito-Smythers, Christianne et al. (2014) Negative cognitive style and perceived social support mediate the relationship between aggression and NSSI in hospitalized adolescents. J Adolesc 37:483-91
Miller, Adam B; Esposito-Smythers, Chrstianne (2013) How Do Cognitive Distortions and Substance Related Problems Affect the Relationship Between Child Maltreatment and Adolescent Suicidal Ideation? Psychol Violence 3:340-353
Wolff, Jennifer; Frazier, Elisabeth A; Esposito-Smythers, Christianne et al. (2013) Cognitive and social factors associated with NSSI and suicide attempts in psychiatrically hospitalized adolescents. J Abnorm Child Psychol 41:1005-13
Weismoore, Julie T; Esposito-Smythers, Christianne (2010) The role of cognitive distortion in the relationship between abuse, assault, and non-suicidal self-injury. J Youth Adolesc 39:281-90
Rizzo, Christie J; Esposito-Smythers, Christianne; Spirito, Anthony et al. (2010) Psychiatric and Cognitive Functioning in Adolescent Inpatients with Histories of Dating Violence Victimization. J Aggress Maltreat Trauma 19:565-583

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