Regulation, and in particular, the ability to cognitively control emotional responses is essential for mental health. Emotion dysregulation lies at the heart of many psychiatric disorders, such as depression. Emotion regulation also may influence physical health, and there is growing evidence that regulation difficulties contribute to the onset and progression of cardiovascular disease and that interventions that improve emotion regulation increase cardiovascular health. What remains unclear, however, are the cognitive and neural mechanisms that underlie our emotion regulatory abilities. This proposal outlines a series of studies that tackle this question using functional magnetic resonance imaging (fMRI) to study the ability to cognitively control emotion. This ability is known as reappraisal, which entails interpreting an emotional stimulus or event in terms that attenuate (i.e. decrease) or enhance (i.e. increase) one's emotional response. Experiments 1-3 are aimed at developing a model of cognitive reappraisal in healthy young adults. We hypothesize, that reappraisal should depend upon prefrontal and cingulate systems that implement cognitive control processes, and should modulate activation of emotion processing systems such as the amygdala, striatum, and orbitofrontal cortex. To test these hypotheses, studies examine the attenuation and enhancement of positive emotions; examine possible mediating component processes, and reappraisal to other forms of regulation. A special aspect of all studies is the inclusion of large participant populations that will allow us to examine the influence on emotion of gender and other individual differences variables that influence emotional responding and regulation. These differences are used to test the model's ability to account for normal variations in emotional experience, and to discover to whom the model best applies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH066957-02
Application #
6890380
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Anderson, Kathleen C
Project Start
2004-05-01
Project End
2007-04-30
Budget Start
2005-07-01
Budget End
2006-04-30
Support Year
2
Fiscal Year
2005
Total Cost
$280,000
Indirect Cost
Name
Stanford University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Dan-Glauser, Elise S; Gross, James J (2013) Emotion regulation and emotion coherence: evidence for strategy-specific effects. Emotion 13:832-42
Ray, Rebecca D; McRae, Kateri; Ochsner, Kevin N et al. (2010) Cognitive reappraisal of negative affect: converging evidence from EMG and self-report. Emotion 10:587-92
McRae, Kateri; Hughes, Brent; Chopra, Sita et al. (2010) The neural bases of distraction and reappraisal. J Cogn Neurosci 22:248-62
Goldin, Philippe R; McRae, Kateri; Ramel, Wiveka et al. (2008) The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biol Psychiatry 63:577-86
Barrett, Lisa Feldman; Mesquita, Batja; Ochsner, Kevin N et al. (2007) The experience of emotion. Annu Rev Psychol 58:373-403
Kreibig, Sylvia D; Wilhelm, Frank H; Roth, Walton T et al. (2007) Cardiovascular, electrodermal, and respiratory response patterns to fear- and sadness-inducing films. Psychophysiology 44:787-806
Ray, Rebecca D; Ochsner, Kevin N; Cooper, Jeffrey C et al. (2005) Individual differences in trait rumination and the neural systems supporting cognitive reappraisal. Cogn Affect Behav Neurosci 5:156-68
Ochsner, Kevin N; Ray, Rebecca D; Cooper, Jeffrey C et al. (2004) For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage 23:483-99