Abstract

EXCEEDTHESPACEPROVIDED. I Despitethefactthatfunctionaml agneticresonanciemaging(fMRI)studieshavebecomeubiquitousandareofeverincreasing importancfeor clinicalandbasicneurosciencesth, efundamentarlelationshipbsetweenbloodoxygenatiolneveldependen(tBOLD) andelectrophysiologicreasl ponsersegardingspatiael xtentandamplitudeis notwellunderstoodN.umerousBOLDstudiesata coarsescale(severaml illimetetro centimeteri)ndicateda faircorrelatiobnetweentheloci of hemodynamicactivityandthe spatialocalizationofbrainfunctionsknown1reintraditionaslingleunitandlesionstudies.Howevert,heBOLDsignalisnota directmeasureofneuronalctivityperse.Ratheri,t isa complexconvolutioonf changesincerebraml etabolicrateofoxygen (CURe2),cerebrabl loodflow(CBF)andcerebrabl loodvolume(CBV)followingfocalneuronalctivity.Thereforea, directand linearcorrelationbetweentheamplitudeoftheobservablBeOLDsignalsandtheunderlyingneuralactivityatthe neurophysiologicalilmy portants,ub-millimetesrcale,canthereforenotbeassumeda priori.Inthepresentstudyw, esuggesto addressthesequestionsinadirectmanner.First,weproposeto performsingle/mulutinitrecordingandBOLDfMRIfromthesame sitesofthecatprimaryvisualcortexusinga novel'Cartesiangrid'techniqurecentlydevelopedinourlaboratoryS. econdw, e willelucidatethecontributioonl spikingandsubthresholdcorticalactivityinthe observedBOLDcontrastbycarefullymapping theextraclassicavlersusclassicarleceptivefieldboundariesA.ndthird,neuroactivceompoundsthatareknownto influencethe balancebetweenexcitatoryandinhibitorycorticalactivitywillbeinfusedfocallyduringfunctionaMl RIscans.Inparticular, theeffectofGABAandbicuculline(GABA-Aantagonisto)ntheamplitudet,imecoursea, ndspatialextendof BOLDsignalswillbe tested.Insummaryw, ebelievethatourprojectwillprovidepivotalinsightsintothefundamentaplointsofcontactbetweenthe observablea,ndubiquitousBOLDcontrasta, nditsunderlyingneurophysiologicoarligin. PERFORMANCE SITE ========================================Section End===========================================

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH067530-05
Application #
6937222
Study Section
Special Emphasis Panel (ZNS1-SRB-R (01))
Program Officer
Anderson, Kathleen C
Project Start
2002-08-15
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
5
Fiscal Year
2005
Total Cost
$267,823
Indirect Cost

  Institution

Name
Boston University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Kim, Dae-Shik (2005) The cutting edge of fMRI and high-field fMRI. Int Rev Neurobiol 66:147-66
Kim, Dae-Shik; Ronen, Itamar; Olman, Cheryl et al. (2004) Spatial relationship between neuronal activity and BOLD functional MRI. Neuroimage 21:876-85