Research in Western countries indicates that neuropsychological (NP) impairment is a common consequence of HIV infection and is associated with reduced everyday functioning and worse medical prognosis (early mortality). China (population 1.3 billion) is seeing an exponential growth in its HIV epidemic. Although differences in host genetics, treatment, and cofactors (e.g., other infections) may result in different neurobehavioral outcomes in China, there has been no research on neuroAIDS there. The Chinese government has placed a high priority on HIV prevention and treatment. With support of the U.S. NIH, the China CDC has initiated the China Comprehensive International Program for Research on AIDS (CIPRA), and is beginning a series of studies on two major HIV risk populations in China: injection drug users (IDUs) and former plasma donors (FPDs). Here we propose the first study of HIV related neurobehavioral disorders in China. In collaboration with colleagues at the China CDC, we will utilize the infrastructure of CIPRA and China CARES (another CDC program for HIV/AIDS) to identifiy large samples of demographically matched HIV+ and HIV- participants within the FPD and 1DU populations (4 groups, each with n=200). Over a 5-year study period, we will clarify the prevalence, nature, clinical significance, and patterns of change in HIV associated NP impairments in these groups. We will determine whether differences in NP impairment are predicted by host genetic characteristics, including specific HLA types and polymorphisms in genes encoding for chemokine receptors, chemokines, and cytokines. Effects of comorbid infection with hepatitis C virus (HCV) also will be examined, because HCV is an independent risk for NP impairment and is highly prevalent in both the IDU and FPD populations. This project extends an existing relationship between the Chinese and U.S. investigators. At an organizational level, the U.S. side will be responsible for overall study progress, training, quality assurance, and data management, while the China side will recruit, track and assess participants. The proposed research will provide detailed new information about neurocognitive and neuropsychiatric complications of HIV disease in China. This increased understanding of the clinical significance of these complications and their determinants in China should better inform clinical management of affected populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH073433-04
Application #
7409105
Study Section
Special Emphasis Panel (ZRG1-AARR-A (07))
Program Officer
Joseph, Jeymohan
Project Start
2005-05-13
Project End
2010-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
4
Fiscal Year
2008
Total Cost
$645,840
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Heaton, Robert K; Akshoomoff, Natacha; Tulsky, David et al. (2014) Reliability and validity of composite scores from the NIH Toolbox Cognition Battery in adults. J Int Neuropsychol Soc 20:588-98
Gupta, Saurabh; Iudicello, Jennifer E; Shi, Chuan et al. (2014) Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment. Drug Alcohol Depend 137:29-35
Grant, Igor; Franklin Jr, Donald R; Deutsch, Reena et al. (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055-62
Jin, Hua; Atkinson, J Hampton; Duarte, Nichole A et al. (2013) Risks and predictors of current suicidality in HIV-infected heroin users in treatment in Yunnan, China: a controlled study. J Acquir Immune Defic Syndr 62:311-6
Weintraub, Sandra; Dikmen, Sureyya S; Heaton, Robert K et al. (2013) Cognition assessment using the NIH Toolbox. Neurology 80:S54-64
Joseph, Jeymohan; Achim, Cristian L; Boivin, Michael J et al. (2013) Global NeuroAIDS roundtable. J Neurovirol 19:1-9
Schrier, Rachel D; Gupta, Saurabh; Riggs, Patricia et al. (2012) The influence of HLA on HIV-associated neurocognitive impairment in Anhui, China. PLoS One 7:e32303
Gupta, Saurabh; Vaida, Florin; Riggs, Katie et al. (2011) Neuropsychological performance in mainland china: the effect of urban/rural residence and self-reported daily academic skill use. J Int Neuropsychol Soc 17:163-73
Atkinson, J Hampton; Jin, Hua; Shi, Chuan et al. (2011) Psychiatric context of human immunodeficiency virus infection among former plasma donors in rural China. J Affect Disord 130:421-8
Cysique, Lucette A; Letendre, Scott L; Ake, Christopher et al. (2010) Incidence and nature of cognitive decline over 1 year among HIV-infected former plasma donors in China. AIDS 24:983-90

Showing the most recent 10 out of 16 publications