Occupational disability is one of the most devastating and costly consequences of severe mental illness (SMI). Supported employment programs such as Individual Placement and Support (IPS) are the most effective way to help people with SMI obtain competitive employment (i.e., """"""""regular jobs"""""""" in the community). However, many clients in supported employment either do not work at all or fail to keep their jobs. The cognitive impairments and everyday functioning skills deficits of psychiatric disorders contribute to poor work outcomes, but they are modifiable with Cognitive Training. Pilot data support the effectiveness of IPS and Cognitive Training for clients with SMI, including those who are middle-aged and older. The proposed research aims to evaluate the effectiveness of augmenting IPS supported employment services with a 3-month Cognitive Training program that aims to improve attention, learning, memory, and problem-solving abilities. The Cognitive Training approach is compensatory, in that it teaches strategies for overcoming cognitive deficits, and aims to help clients develop better thinking and memory habits that will last a lifetime. In the proposed 24- month randomized controlled trial, 152 participants with SMI will receive either IPS with Cognitive Training (IPS-CT) or IPS with enhanced support (IPS-ES). The IPS vocational specialist will deliver the Cognitive Training intervention in the client's community setting of choice, along with standard IPS services (job searching, job development, and follow-along job supports). IPS-ES will control for the additional time and attention provided in the IPS-CT condition during the first 3 months. All participants will be followed for 24 months, and employment data will be collected weekly. The primary aim of the study is to evaluate the hypothesis that compared to IPS-ES, IPS-CT will result in improved cognition, functional skills, work outcomes (e.g., number of weeks worked), and quality of life. Secondary aims are to investigate the mechanisms underlying such improvements and to identify predictors of employment outcomes. If Cognitive Training is found to improve outcomes in supported employment, the psychiatric rehabilitation field will be better prepared to help clients across the age spectrum meet their vocational and community reintegration goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH080150-05
Application #
8234175
Study Section
Mental Health Services in MH Specialty Settings (SRSP)
Program Officer
Juliano-Bult, Denise M
Project Start
2008-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$285,287
Indirect Cost
$54,370
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Mahmood, Zanjbeel; Burton, Cynthia Z; Vella, Lea et al. (2018) Neuropsychological predictors of performance-based measures of functional capacity and social skills in individuals with severe mental illness. J Psychiatr Res 102:201-206
Burton, Cynthia Z; Vella, Lea; Twamley, Elizabeth W (2018) Prospective memory, level of disability, and return to work in severe mental illness. Clin Neuropsychol :1-12
Obermeit, Lisa C; Beltran, Jessica; Casaletto, Kaitlin B et al. (2017) Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining ""symptomatic"" versus ""asymptomatic"" HAND. J Neurovirol 23:67-78
Thomas, Kelsey R; Puig, Olga; Twamley, Elizabeth W (2017) Age as a moderator of change following compensatory cognitive training in individuals with severe mental illnesses. Psychiatr Rehabil J 40:70-78
Vella, Lea; Patterson, Thomas L; Harvey, Philip D et al. (2017) Exploratory analysis of normative performance on the UCSD Performance-Based Skills Assessment-Brief. Psychiatry Res 256:150-155
Joseph, Jamie; Kremen, William S; Franz, Carol E et al. (2017) Predictors of current functioning and functional decline in schizophrenia. Schizophr Res 188:158-164
Puig, Olga; Thomas, Kelsey R; Twamley, Elizabeth W (2016) Age and Improved Attention Predict Work Attainment in Combined Compensatory Cognitive Training and Supported Employment for People With Severe Mental Illness. J Nerv Ment Dis 204:869-872
Ma, Qing; Vaida, Florin; Wong, Jenna et al. (2016) Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients. J Neurovirol 22:170-8
Mendella, Paul D; Burton, Cynthia Z; Tasca, Giorgio A et al. (2015) Compensatory cognitive training for people with first-episode schizophrenia: results from a pilot randomized controlled trial. Schizophr Res 162:108-11
Joseph, Jamie; Kremen, William S; Glatt, Stephen J et al. (2015) Assessment of Lifespan Functioning Attainment (ALFA) scale: A quantitative interview for self-reported current and functional decline in schizophrenia. J Psychiatr Res 65:102-7

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