One third to one half of psychiatrically hospitalized youth is readmitted, with highest readmission risk 15-30 days post discharge and more than 80% readmitted within three months. The proposed study involves in vivo characterization of naturalistic phenomena associated with suicide risk after discharge adolescents using ecological methods and devices that allow acoustic capture of an individual's social environment and self-reports of experienced affect. We propose that social context and experienced affect are reciprocally reinforcing and that a reactive style involving close coupling of stressful social context (isolation, conflictual or high affect interactions) with affect reactivity (rapidly changig, intense affect, with slow return to baseline) increases risk for suicidal thoughts and behaviors. We also examine childhood maltreatment and epigenetic markers as predictors of post-discharge reactivity. Two hundred youth hospitalized for suicidal thoughts and behaviors will be followed prospectively using ecological methods and devices for three weeks following psychiatric discharge; suicidal thoughts and behaviors will be reassessed at 6 months. The present study further innovates through the incorporation of affect reactivity biomarkers (in-hospital blood samples for assessment of DNA/DNAm/expression). The proposed study merges multiple fields of study and permits an innovative and thorough characterization of the real-world interplay of affect and social context. Results of this investigation will inform a number of intervention approaches including family therapy, EMA-based adjunctive intervention, and pharmacological approaches.

Public Health Relevance

Adolescents hospitalized for suicidal thoughts and behaviors are at high risk for rehospitalization and suicide attempts during initial weeks following discharge. The present study involves a rich characterization of adolescents' emotions and social interactions in the weeks following psychiatric hospitalization discharge using the combination of self-reporting on mobile devices and audio capture of social environment. The study also examines the ways that early life maltreatment may impact the emotional and social processes experienced by discharged adolescents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH105379-01
Application #
8796531
Study Section
Social Psychology, Personality and Interpersonal Processes Study Section (SPIP)
Program Officer
Garriock, Holly A
Project Start
2015-03-01
Project End
2020-02-28
Budget Start
2015-03-01
Budget End
2016-02-29
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
Wolf, Erika J; Maniates, Hannah; Nugent, Nicole et al. (2018) Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology 92:123-134
Marraccini, Marisa E; Brick, Leslie Ann D; Weyandt, Lisa L (2018) Instructor and peer bullying in college students: Distinct typologies based on Latent Class Analysis. J Am Coll Health :1-12
Lind, Mackenzie J; Marraccini, Marisa E; Sheerin, Christina M et al. (2017) Association of Posttraumatic Stress Disorder With rs2267735 in the ADCYAP1R1 Gene: A Meta-Analysis. J Trauma Stress 30:389-398
Sheerin, Christina M; Lind, Mackenzie J; Bountress, Kaitlin et al. (2017) The Genetics and Epigenetics of PTSD: Overview, Recent Advances, and Future Directions. Curr Opin Psychol 14:5-11
Barker, David H; Nugent, Nicole R; Delgado, Jeanne R et al. (2017) A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking. AIDS Care 29:1186-1191
Bountress, Kaitlin E; Bacanu, Silviu-Alin; Tomko, Rachel L et al. (2017) The Effects of a BDNF Val66Met Polymorphism on Posttraumatic Stress Disorder: A Meta-Analysis. Neuropsychobiology 76:136-142
Mehl, Matthias R (2017) The Electronically Activated Recorder (EAR): A Method for the Naturalistic Observation of Daily Social Behavior. Curr Dir Psychol Sci 26:184-190
Marraccini, Marisa E; Brier, Zoe M F (2017) School connectedness and suicidal thoughts and behaviors: A systematic meta-analysis. Sch Psychol Q 32:5-21
Marraccini, Marisa E; Weyandt, Lisa L; Rossi, Joseph S et al. (2016) Neurocognitive enhancement or impairment? A systematic meta-analysis of prescription stimulant effects on processing speed, decision-making, planning, and cognitive perseveration. Exp Clin Psychopharmacol 24:269-84
Nugent, Nicole R; Goldberg, Amy; Uddin, Monica (2016) Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health. J Pediatr Psychol 41:55-64

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