Extensive research finds robust links between mental health and childhood adversity (CA), encompassing diverse exposures from child abuse to poverty. Despite the strength and consistency of these findings, the mechanisms producing such links remain poorly specified. In particular, past research has failed to identify how specifi environmental experiences influence specific neural processes. Such limitations arise from the difficulty of precisely quantifying relevant CA and neural variables in children. The current proposal addresses these limitations by capitalizing on a unique, well characterized NIH-funded longitudinal cohort of children where multiple aspects of CA have been precisely assessed and use of rigorous neuroimaging methods to quantify functioning in specific neural circuits. We will use these methods to test a novel conceptual framework delineating how specific types of environmental experience influence specific neural processes, addressing Objective 1 of the NIMH Strategic Plan. Our model argues that different types of CA have distinct effects on neural development. The central distinction we make is between trauma and deprivation. Trauma exposure involves harm or threat of harm, resulting in fear learning mediated by limbic pathways that are well characterized in animals and conserved across species. We argue that child trauma alters development of circuits in the Negative Valence System that support emotional learning encompassing amygdala and ventromedial prefrontal cortex (PFC). In contrast, deprivation involves absence of expected cognitive and social inputs and environmental complexity. Animal research shows that deprivation disrupts development in PFC and parietal cortex by hijacking the typical process of synaptic pruning. Thus we predict that social-cognitive deprivation influences Cognitive Control Systems, resulting in age-specific reductions in thickness and volume of dorsolateral PFC and superior parietal cortex and reduced performance on cognitive control tasks supported by these areas. Clearly, trauma and deprivation are correlated. Our unique design will measure these experiences on separate dimensions informed by rich preliminary data indicating distinct effects of trauma and deprivation on neural development even in samples with high exposure co-occurrence. Our proposed conceptual model will be tested by acquiring structural and functional MRI data on an existing sample of 300 children (1/3 in poverty, 1/3 near poverty, and 1/3 middle class) followed since early childhood with significant variability in CA exposure. Psychopathology has been measured in previous waves of the study and will be collected multiple times during the study period. Study findings will provide critical information about how specific dimensions of environmental experience influence specific neural processes. Elucidating these mechanisms will not only build knowledge of how adverse environments alter neural development in ways that increase risk for psychopathology, but will also suggest possible targets for preventive interventions aimed at reducing psychopathology risk in children exposed to trauma and deprivation.

Public Health Relevance

The proposed research examines the impact of child trauma and deprivation on the development of neural networks involved in emotion regulation and cognitive control in a unique, well characterized NIH-funded longitudinal cohort of children where exposure to environmental adversity has been precisely quantified. We will test a conceptual model based on extensive preliminary data suggesting that different types of environmental experience have distinct effects on neural development by examining the influence of trauma and deprivation on neural structure, including cortical thickness and white matter microstructure, and neural function in Negative Valence Systems (function and connectivity in amygdala-ventromedial PFC network during fear conditioning and extinction) and Cognitive Control Systems (function and connectivity in fronto- parietal networks during cognitive control tasks). Elucidating these mechanisms will not only build knowledge of how adverse environments alter neural development in ways that might increase risk for psychopathology, but will also suggest possible targets for preventive interventions aimed at reducing psychopathology risk in children exposed to environmental adversity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH106482-03
Application #
9382907
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Borja, Susan
Project Start
2015-12-10
Project End
2020-11-30
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Washington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Madhyastha, Tara; Peverill, Matthew; Koh, Natalie et al. (2018) Current methods and limitations for longitudinal fMRI analysis across development. Dev Cogn Neurosci 33:118-128
Sheridan, Margaret A; McLaughlin, Katie A; Winter, Warren et al. (2018) Early deprivation disruption of associative learning is a developmental pathway to depression and social problems. Nat Commun 9:2216
Logue, Mark W; van Rooij, Sanne J H; Dennis, Emily L et al. (2018) Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biol Psychiatry 83:244-253
Jenness, Jessica L; Rosen, Maya L; Sambrook, Kelly A et al. (2018) Violence exposure and neural systems underlying working memory for emotional stimuli in youth. Dev Psychopathol 30:1517-1528
Rosen, Maya L; Sheridan, Margaret A; Sambrook, Kelly A et al. (2018) Socioeconomic disparities in academic achievement: A multi-modal investigation of neural mechanisms in children and adolescents. Neuroimage 173:298-310
Platt, Jonathan M; Keyes, Katherine M; McLaughlin, Katie A et al. (2018) Intellectual disability and mental disorders in a US population representative sample of adolescents. Psychol Med :1-10
Nook, Erik C; Sasse, Stephanie F; Lambert, Hilary K et al. (2018) The Nonlinear Development of Emotion Differentiation: Granular Emotional Experience Is Low in Adolescence. Psychol Sci 29:1346-1357
Miller, Adam Bryant; Sheridan, Margaret A; Hanson, Jamie L et al. (2018) Dimensions of deprivation and threat, psychopathology, and potential mediators: A multi-year longitudinal analysis. J Abnorm Psychol 127:160-170
Miller, Adam Bryant; McLaughlin, Katie A; Busso, Daniel S et al. (2018) Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation. Biol Psychiatry Cogn Neurosci Neuroimaging 3:125-132
Duffy, Korrina A; McLaughlin, Katie A; Green, Paige A (2018) Early life adversity and health-risk behaviors: proposed psychological and neural mechanisms. Ann N Y Acad Sci 1428:151-169

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