Positron Emission Tomography (PET) is a medical technique that creates images of biochemical processes occurring in vivo, where radioactive molecules are injected and the distributions of those molecules are measured using a PET scanner. Data can be acquired in animals, in research subjects and eventually in patient care. As the burden of psychiatric illnesses in the United States and worldwide is high, there is a critical need to develop novel PET radiopharmaceuticals to image illness-related processes in the brain. This work will develop key tools designed to advance the scientific understanding of metabotropic glutamate receptor 2 in the glutamatergic signaling system and facilitate the discovery of neurotherapeutics.
| Chen, Zhen; Mori, Wakana; Zhang, Xiaofei et al. (2018) Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging ?8-dependent transmembrane AMPA receptor regulatory protein. Eur J Med Chem 157:898-908 |
