This proposed study will apply an extensively tested nursing intervention to post-surgical cancer patients who are newly diagnosed with advanced cancer. Symptom distress, unmet treatment goals, complications, emergency visits, and costly readmissions to the hospital are common when patients at high risk for post- operative complications are discharged from the hospital with unmet needs and fragmented care. The study's overall purpose is to implement our evidence based Advanced Practice Nurse (APN) intervention using the RE-AIM model (Reach, Efficacy, Adoption, Implementation, Maintenance) to evaluate clinical outcomes and the sustainability of the intervention in medical oncology.
The specific aims are to: 1) Integrate discharge planning into an intervention provided by an oncology APN for high risk adults with advanced cancer after surgery;2) Evaluate the effects of the nursing intervention provided by APNs to patients with advanced cancer after surgery to improve clinical outcomes, reduce complications and health care utilization;and 3) Explore the reach, adoption, implementation, and maintenance of a nursing intervention delivered by APNs to facilitate the transition of patients from surgery to medical oncology in a comprehensive cancer center. A cluster randomization procedure will assign disease specific medical oncology clinics at Yale Comprehensive Cancer Center into 2 groups: a treatment group (who will implement the APN intervention) and an enhanced control group (who will provide the standard usual care plus a copy of the symptom management toolkit with instructions on its use). One hundred and forty patients with advanced cancer recruited from the surgical units at Yale New Haven Hospital will provide outcome data that will be compared at 3 data points (baseline, 1 and 3 months post-surgery). The effects of the discharge coordination and APN intervention will be evaluated using self-report questionnaires and health care utilization outcomes. The adoption, implementation, and maintenance process variables will be evaluated through documentation and interviews. This application provides a unique opportunity to implement our intervention in transitioning patients across settings: in-patient to ambulatory care and improving the quality of their lives throughout the illness trajectory. The results will be used to submit a multi-site clinical trial.

Public Health Relevance

This proposed study will apply an evidence-based nursing intervention to post-surgical patients who are newly diagnosed with advanced cancer. The intervention will facilitate patients'transitions between services (surgery to medical oncology) and settings (inpatient to ambulatory care). The intervention will jump start patients'introduction to palliative care at the beginning of their diagnosis and treatment in order to maximize their journey throughout the illness trajectory.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR011872-03
Application #
8123342
Study Section
Special Emphasis Panel (ZNR1-REV-W (04))
Program Officer
Wasserman, Joan
Project Start
2009-09-29
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2011
Total Cost
$451,603
Indirect Cost
Name
Yale University
Department
Type
Schools of Nursing
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Bai, Mei; Lazenby, Mark (2015) A systematic review of associations between spiritual well-being and quality of life at the scale and factor levels in studies among patients with cancer. J Palliat Med 18:286-98
McCorkle, Ruth; Jeon, Sangchoon; Ercolano, Elizabeth et al. (2015) An Advanced Practice Nurse Coordinated Multidisciplinary Intervention for Patients with Late-Stage Cancer: A Cluster Randomized Trial. J Palliat Med 18:962-9
Bai, Mei; Lazenby, Mark; Jeon, Sangchoon et al. (2015) Exploring the relationship between spiritual well-being and quality of life among patients newly diagnosed with advanced cancer. Palliat Support Care 13:927-35
Bai, Mei; Dixon, Jane K (2014) Exploratory factor analysis of the 12-item Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale in people newly diagnosed with advanced cancer. J Nurs Meas 22:404-20
Lazenby, Mark; Dixon, Jane; Bai, Mei et al. (2014) Comparing the distress thermometer (DT) with the patient health questionnaire (PHQ)-2 for screening for possible cases of depression among patients newly diagnosed with advanced cancer. Palliat Support Care 12:63-8
Fodeh, Samah J; Lazenby, Mark; Bai, Mei et al. (2013) Functional impairments as symptoms in the symptom cluster analysis of patients newly diagnosed with advanced cancer. J Pain Symptom Manage 46:500-10
McCorkle, Ruth; Ercolano, Elizabeth; Lazenby, Mark et al. (2011) Self-management: Enabling and empowering patients living with cancer as a chronic illness. CA Cancer J Clin 61:50-62