Our objective is to understand the functioning of excitable cells, with emphasis on neurons, at the membrane and cellular levels. We use the voltage clamp to study the effect of potential patterns on membrane conductances in normal media and when physical changes are made or chemical agents added. We seek to encompass these observations (and those of others) into an improved mathematical model. At the cellular level we are investigating how geometrical and membrane changes affect impulse conduction.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS003437-27
Application #
3393291
Study Section
Physiology Study Section (PHY)
Project Start
1978-09-01
Project End
1988-09-24
Budget Start
1987-09-01
Budget End
1988-09-24
Support Year
27
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Lindgren, C A; Moore, J W (1989) Identification of ionic currents at presynaptic nerve endings of the lizard. J Physiol 414:201-22
Hayashi, J H; Moore, J W; Stuart, A E (1985) Adaptation in the input-output relation of the synapse made by the barnacle's photoreceptor. J Physiol 368:179-95