Abstract

Our current research is focused on two different but related problems: 1) that of stimulation-produced analgesia from brain stem electrical stimulation in the rat; and 2) that of the normal physiological circumstances calling into action the brain's own pain-inhibitory systems. Within each of these domains we have recent evidence for the coexistence of opioid and nonopioid systems. Our studies of these mechanisms are continuing with the application of both biochemical and electrophysiological techniques to supplement the behavioral and pharmacological approaches already taken.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS007628-18
Application #
3393610
Study Section
Biopsychology Study Section (BPO)
Project Start
1976-12-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
18
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Sternberg, W F; Mogil, J S; Pilati, M L et al. (1994) Neurochemical quality of nonopioid stress-induced analgesia is not altered by estrous phase in female mice. Proc West Pharmacol Soc 37:141-3
Kest, B; Mogil, J S; Sternberg, W F et al. (1994) Haloperidol increases pain behavior following peripheral tissue injury. Proc West Pharmacol Soc 37:89-90
Mogil, J S; Marek, P; O'Toole, L A et al. (1994) Mu-opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia. Brain Res 653:16-22
Page, G G; Ben-Eliyahu, S; Liebeskind, J C (1994) The role of LGL/NK cells in surgery-induced promotion of metastasis and its attenuation by morphine. Brain Behav Immun 8:241-50
Page, G G; Ben-Eliyahu, S; Yirmiya, R et al. (1993) Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain 54:21-8
Kest, B; Mogil, J S; Sternberg, W F et al. (1993) Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia. Proc West Pharmacol Soc 36:249-53
Marek, P; Mogil, J S; Belknap, J K et al. (1993) Levorphanol and swim stress-induced analgesia in selectively bred mice: evidence for genetic commonalities. Brain Res 608:353-7
Mogil, J S; Sternberg, W F; Kest, B et al. (1993) Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain 53:17-25
Ben-Eliyahu, S; Page, G G; Marek, P et al. (1993) The NMDA receptor antagonist MK-801 blocks nonopioid stress induced analgesia and decreases tumor metastasis in the rat. Proc West Pharmacol Soc 36:293-8
Vaccarino, A L; Marek, P; Kest, B et al. (1993) Morphine fails to produce tolerance when administered in the presence of formalin pain in rats. Brain Res 627:287-90

Showing the most recent 10 out of 74 publications