The aim of this project is to develop information on and insight into the molecular mechanisms by which cell membranes generate signals, i.e., the nervous impulse. Studies are aimed at further elucidation of the way in which the gating machinery for the sodium, and also the potassium, channel is organized utilizing the methods of relaxation kinetics on internally perfused, voltage clamped giant axons. In addition, studies will be carried out on the nature of the process by which ions traverse cell membranes, by observing the selectivity properties of both the sodium and potassium channels.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS007734-13S2
Application #
3393646
Study Section
Physiology Study Section (PHY)
Project Start
1976-05-01
Project End
1986-08-31
Budget Start
1985-06-01
Budget End
1986-08-31
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201