The purpose of the proposed study is to increase our understanding of how the motor cortex controls movement and subsequently to contribute toward the better treatment of human motor dysfunctions. During the past grant years, we have shown that the motor cortex receives peripheral inputs directly from the thalamus and not through the sensory cortex. We have already shown there are cortical efferent zones within the motor cortex which control contraction of individual muscles, hence the motor cortex and the periphery are connected by the simplest loop circuit. During the coming years, we plan to elucidate the functional significance of various inputs converging into the motor cortex. This will be done by delivering microstimulation to various parts of the central nervous system and examining the effects using the cortico-peripheral loop circuit. The study will hopefully explore further insights of the motor cortex and yield knowledge which will be applicable to the treatment of the patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS010705-14
Application #
3394287
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1978-09-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
Graduate Schools
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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Kaneko, T; Caria, M A; Asanuma, H (1994) Information processing within the motor cortex. II. Intracortical connections between neurons receiving somatosensory cortical input and motor output neurons of the cortex. J Comp Neurol 345:172-84
Kaneko, T; Caria, M A; Asanuma, H (1994) Information processing within the motor cortex. I. Responses of morphologically identified motor cortical cells to stimulation of the somatosensory cortex. J Comp Neurol 345:161-71
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Keller, A; Asanuma, H (1993) Synaptic relationships involving local axon collaterals of pyramidal neurons in the cat motor cortex. J Comp Neurol 336:229-42
Pavlides, C; Miyashita, E; Asanuma, H (1993) Projection from the sensory to the motor cortex is important in learning motor skills in the monkey. J Neurophysiol 70:733-41
Keller, A; Arissian, K; Asanuma, H (1992) Synaptic proliferation in the motor cortex of adult cats after long-term thalamic stimulation. J Neurophysiol 68:295-308
Asanuma, H; Keller, A (1991) Neuronal mechanisms of motor learning in mammals. Neuroreport 2:217-24
Keller, A; Miyashita, E; Asanuma, H (1991) Minimal stimulus parameters and the effects of hyperpolarization on the induction of long-term potentiation in the cat motor cortex. Exp Brain Res 87:295-302
Iriki, A; Pavlides, C; Keller, A et al. (1991) Long-term potentiation of thalamic input to the motor cortex induced by coactivation of thalamocortical and corticocortical afferents. J Neurophysiol 65:1435-41

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