Biochemical studies on proteins of the lumbar spinal cord, ventral roots and isolated spinal motoneurons are to be performed on frogs whose 9th and 10th ventral roots have been transected. Neurotransmitter-related enzymes and structural proteins will be examined for alterations in activity, mass, and relative rates of synthesis and degradation. These studies should help elucidate the biochemical mechanisms by which spinal motoneurons respond to injury of their axons.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS012103-13
Application #
3394708
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1978-07-01
Project End
1992-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
13
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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McIlwain, D L; Hoke, V B (1988) Allocation of newly synthesized proteins in spinal motoneurons. Rev Neurol (Paris) 144:697-700
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