Abstract

We are conducting a coordinated program of neurophysiological, neuroanatomical, endocrinological and biochemical research on the sensory and hormonal basis of olfactory discrimination in mammals. The objectives of the research include (1) chemical identification of biologically active constituents in pheromonal secretions, (2) study of the mechanisms by which these substances affect neuroendocrine and reproductive functions, (3) characterization of the mechanisms by which changes in hormonal secretion influence the neural processing of biologically relevant stimuli, (4) specification of the anatomical and neurochemical relationships among structures of the olfactory and limbic-hypothalamic systems, and (5) examination of the functional significance of reciprocal connections among these forebrain structures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS012344-12
Application #
3394822
Study Section
Endocrinology Study Section (END)
Project Start
1978-07-01
Project End
1988-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
12
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Worcester Foundation for Biomedical Research
Department
Type
DUNS #
City
Shrewsbury
State
MA
Country
United States
Zip Code
01545

  Publications

Clancy, A N; Schoenfeld, T A; Forbes, W B et al. (1994) The spatial organization of the peripheral olfactory system of the hamster. Part II: Receptor surfaces and odorant passageways within the nasal cavity. Brain Res Bull 34:211-41
Schoenfeld, T A; Clancy, A N; Forbes, W B et al. (1994) The spatial organization of the peripheral olfactory system of the hamster. Part I: Receptor neuron projections to the main olfactory bulb. Brain Res Bull 34:183-210
Henzel, W J; Rodriguez, H; Singer, A G et al. (1988) The primary structure of aphrodisin. J Biol Chem 263:16682-7
Clancy, A N; Singer, A G; Macrides, F et al. (1988) Experiential and endocrine dependence of gonadotropin responses in male mice to conspecific urine. Biol Reprod 38:183-91
Singer, A G; Clancy, A N; Macrides, F et al. (1988) Chemical properties of a female mouse pheromone that stimulates gonadotropin secretion in males. Biol Reprod 38:193-9
Singer, A G; Agosta, W C; Clancy, A N et al. (1987) The chemistry of vomeronasally detected pheromones: characterization of an aphrodisiac protein. Ann N Y Acad Sci 519:287-98
Kream, R M; Clancy, A N; Kumar, M S et al. (1987) Substance P and luteinizing hormone-releasing hormone levels in the brain of the male golden hamster are both altered by castration and testosterone replacement. Neuroendocrinology 46:297-305
Macrides, F; Schoenfeld, T A; Clancy, A N et al. (1987) Hormones and neurotransmitters in the mammalian olfactory system. Ann N Y Acad Sci 519:150-64
Clancy, A N; Goldman, B D; Bartke, A et al. (1986) Reproductive effects of olfactory bulbectomy in the Syrian hamster. Biol Reprod 35:1202-9
Singer, A G; Macrides, F; Clancy, A N et al. (1986) Purification and analysis of a proteinaceous aphrodisiac pheromone from hamster vaginal discharge. J Biol Chem 261:13323-6

Showing the most recent 10 out of 11 publications