Abstract

The objectives of this research project are to investigate possible developmental roles of neurotransmitters (the monoamines) in early phases of neuroembryogenesis (neural tube closure and the time of origin of their prospective target cells) and the modulation of this ontogenetic regulation by hormones (the steroids). Various methods will be employed in these studies of early neurogenesis in the rat and chick, including light and electron microscopic autoradiography, fluorescence histochemistry, immunocytochemistry and radioenzymatic microassays. The effects of monoamine-depleting drugs, stress, diet, and the hormonal integrity of the pregnant rat on fetal brain development will also be explored in the same experimental context. The results of these studies bear direct relevance to the problems of neural tube defects and mechanisms underlying the initial phase of circuitry construction in the developing brain.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS015706-07
Application #
3396440
Study Section
(NY)
Project Start
1979-01-01
Project End
1986-06-30
Budget Start
1985-01-01
Budget End
1986-06-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Lauder, J M; Liu, J (1994) Glial heterogeneity and developing neurotransmitter systems. Perspect Dev Neurobiol 2:239-50
Schambra, U B; Lauder, J M; Petrusz, P et al. (1990) Development of neurotransmitter systems in the mouse embryo following acute ethanol exposure: a histological and immunocytochemical study. Int J Dev Neurosci 8:507-22
Lauder, J M (1990) Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann N Y Acad Sci 600:297-313;discussion 314
Granger, N A; Homberg, U; Henderson, P et al. (1989) Serotonin-immunoreactive neurons in the brain of Manduca sexta during larval development and larval-pupal metamorphosis. Int J Dev Neurosci 7:55-72
Schambra, U B; Sulik, K K; Petrusz, P et al. (1989) Ontogeny of cholinergic neurons in the mouse forebrain. J Comp Neurol 288:101-22
Konig, N; Wilkie, M B; Lauder, J M (1988) Tyrosine hydroxylase and serotonin containing cells in embryonic rat rhombencephalon: a whole-mount immunocytochemical study. J Neurosci Res 20:212-23
Han, V K; Lauder, J M; D'Ercole, A J (1988) Rat astroglial somatomedin/insulin-like growth factor binding proteins: characterization and evidence of biologic function. J Neurosci 8:3135-43
Jin, S L; Han, V K; Simmons, J G et al. (1988) Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study. J Comp Neurol 271:519-32
Lauder, J M; Zimmerman, E F (1988) Sites of serotonin uptake in epithelia of the developing mouse palate, oral cavity, and face: possible role in morphogenesis. J Craniofac Genet Dev Biol 8:265-76
Han, V K; Snouweart, J; Towle, A C et al. (1987) Cellular localization of tyrosine hydroxylase mRNA and its regulation in the rat adrenal medulla and brain by in situ hybridization with an oligodeoxyribonucleotide probe. J Neurosci Res 17:11-8

Showing the most recent 10 out of 16 publications