Abstract

THe proposed experiments are designed to investigate the relationship between recovery of motor function following injury to the CNS and the anatomical plasticity specifically collateral sprouting, of the remaining undamaged systems. The methods used will be behavioral and anatomical. The hypothesis underlying these experiments is that converging systems are not equipotential but that they are ordered hierarchically and therefore that the pattern of recovery will be defined by one of the systems which remains. We propose also to examine the relationship between recovery or sparing of function and anatomical plasticity after neonatal lesion to determine to what extent limitations placed on recovery or sprouting develop postnatally.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS016629-09
Application #
3397017
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1981-09-01
Project End
1991-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129

  Publications

Helgren, M E; Goldberger, M E (1993) The recovery of postural reflexes and locomotion following low thoracic hemisection in adult cats involves compensation by undamaged primary afferent pathways. Exp Neurol 123:17-34
Polistina, D C; Murray, M; Goldberger, M E (1990) Plasticity of dorsal root and descending serotoninergic projections after partial deafferentation of the adult rat spinal cord. J Comp Neurol 299:349-63
Goldberger, M E; Murray, M (1988) Patterns of sprouting and implications for recovery of function. Adv Neurol 47:361-85
Goldberger, M E (1988) Spared-root deafferentation of a cat's hindlimb: hierarchical regulation of pathways mediating recovery of motor behavior. Exp Brain Res 73:329-42
Goldberger, M E (1988) Partial and complete deafferentation of cat hindlimb: the contribution of behavioral substitution to recovery of motor function. Exp Brain Res 73:343-53
Ungar-Sargon, J; Goldberger, M E (1987) Maintenance of specificity by sprouting and regenerating peripheral nerves. II. Variability after lesions. Brain Res 407:124-36
Ungar-Sargon, J; Goldberger, M E (1987) Maintenance of specificity by sprouting and regenerating peripheral nerves. I. Normal variability. Brain Res 407:117-23
Leonard, C T; Goldberger, M E (1987) Consequences of damage to the sensorimotor cortex in neonatal and adult cats. I. Sparing and recovery of function. Brain Res 429:1-14
Leonard, C T; Goldberger, M E (1987) Consequences of damage to the sensorimotor cortex in neonatal and adult cats. II. Maintenance of exuberant projections. Brain Res 429:15-30
Robinson, G A; Goldberger, M E (1986) The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery. Exp Brain Res 62:387-400

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