Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS017423-13
Application #
2263199
Study Section
Neurology C Study Section (NEUC)
Project Start
1981-09-01
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1997-06-30
Support Year
13
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Rock, M T; Brooks, W H; Roszman, T L (1997) Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events. J Biol Chem 272:33377-83
Elliott, L H; Levay, A K; Sparks, B et al. (1996) Dexamethasone and prostaglandin E2 modulate T-cell receptor signaling through a cAMP-independent mechanism. Cell Immunol 169:117-24
Selliah, N; Bartik, M M; Carlson, S L et al. (1995) cAMP accumulation in T-cells inhibits anti-CD3 monoclonal antibody-induced actin polymerization. J Neuroimmunol 56:107-12
Bauman, G P; Bartik, M M; Brooks, W H et al. (1994) Induction of cAMP-dependent protein kinase (PKA) activity in T cells after stimulation of the prostaglandin E2 or the beta-adrenergic receptors: relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation. Cell Immunol 158:182-94
Carlson, S L; Trauth, K; Brooks, W H et al. (1994) Enhancement of beta-adrenergic-induced cAMP accumulation in activated T-cells. J Cell Physiol 161:39-48
Bartik, M M; Bauman, G P; Brooks, W H et al. (1994) Costimulatory signals modulate the antiproliferative effects of agents that elevate cAMP in T cells. Cell Immunol 158:116-30
Elliott, L; Brooks, W; Roszman, T (1993) Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation and interleukin-2 secretion by physiologic combinations of dexamethasone and prostaglandin E2. Cell Mol Neurobiol 13:579-92
Bartik, M M; Brooks, W H; Roszman, T L (1993) Modulation of T cell proliferation by stimulation of the beta-adrenergic receptor: lack of correlation between inhibition of T cell proliferation and cAMP accumulation. Cell Immunol 148:408-21
Elliott, L; Brooks, W; Roszman, T (1992) Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation by dexamethasone, isoproterenol, or prostaglandin E2 either alone or in combination. Cell Mol Neurobiol 12:411-27
Roszman, T L; Brooks, W H (1992) Signaling pathways of the neuroendocrine-immune network. Chem Immunol 52:170-90

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