Abstract

This is a proposal to continue work already underway on the prevention of the intracranial arterial necrosis associated with subarachnoid hemorrhage. Previous work has demonstrated that this vasculopathy can be markedly reduced by the injection of the thromboletic agent Plasmin directly into the cisterna magna. This proposal is to further characterize the proper timing to insure maximal protection and to determine if prevention of the vasculopathy will also prevent delayed vasospasm.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS018522-04A1
Application #
3398550
Study Section
Neurology A Study Section (NEUA)
Project Start
1982-09-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Yoshida, S; Alksne, J F; Seelig, J M et al. (1989) Effect of uridine 5'-diphosphate on cryogenic brain edema in rabbits. Stroke 20:1694-9
Alksne, J F; Branson, P J; Bailey, M (1986) Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin. Neurosurgery 19:20-5