Migraine headache is a common, recurrent, severe and often incapacitating condition estimated to affect 4-19% of adult men and 8-29% of adult women. One survey showed that severe headache is responsible for almost 10 million outpatient visits to physicians per year. The primary objectives of the proposed two-phase study are 1) to determine the prevalence of migraine, 2) to further refine the definition of a case of migraine and to characterize migraine subtypes 3) to identify important risk factors associated with the development and onset of migraine headaches in recent-onset cases in a community population and 4) to identify events which precipitate specific episodes of migraine headache among cases. These objectives will be accomplished by a study consisting of two phases. First, we will conduct a population-based prevalence survey in a well-characterized American community. Second, we will perform a case-control study using 220 recent-onset (incident) migraine cases identified in the prevalence survey. The proposed population-based prevalence study would be one of the first to be carried out in an American community; results could be compared to those from other population-based epidemiologic studies carried out in Great-Britain, Israel and Denmark. The methods used in the prevalence survey will provide a means to estimate the incidence of migraine. This would be unique in that we have been unable to find reports of any other incidence study. In the prevalence survey subjects who have had a recent attack of migraine will be asked about factors which may have precipitated the attack. In contrast to a number of past studies, this study will provide more reliable data on possible precipitants. Finally, a case-control study using recent-onset cases should allow us to focus on more specific hypotheses regarding risk factors suggested by previous work, including stress, psychosocial and personality factors; hormonal factors in women; and familial factors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS019381-01A2
Application #
3399429
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1985-09-09
Project End
1987-08-31
Budget Start
1985-09-09
Budget End
1986-08-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Johannes, C B; Linet, M S; Stewart, W F et al. (1995) Relationship of headache to phase of the menstrual cycle among young women: a daily diary study. Neurology 45:1076-82
Lipton, R B; Silberstein, S D; Stewart, W F (1994) An update on the epidemiology of migraine. Headache 34:319-28
Stewart, W F; Lipton, R B (1993) Migraine headache: epidemiology and health care utilization. Cephalalgia 13 Suppl 12:41-6
Lipton, R B; Stewart, W F (1993) Migraine in the United States: a review of epidemiology and health care use. Neurology 43:S6-10
Lipton, R B; Stewart, W F; Celentano, D D et al. (1992) Undiagnosed migraine headaches. A comparison of symptom-based and reported physician diagnosis. Arch Intern Med 152:1273-8
Stewart, W F; Lipton, R B; Celentano, D D et al. (1992) Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA 267:64-9
Linet, M S; Ziegler, D K; Stewart, W F (1992) Headaches preceded by visual aura among adolescents and young adults. A population-based survey. Arch Neurol 49:512-6
Celentano, D D; Stewart, W F; Lipton, R B et al. (1992) Medication use and disability among migraineurs: a national probability sample survey. Headache 32:223-8
Stewart, W F; Shechter, A; Liberman, J (1992) Physician consultation for headache pain and history of panic: results from a population-based study. Am J Med 92:35S-40S
Brandt, J; Celentano, D; Stewart, W et al. (1990) Personality and emotional disorder in a community sample of migraine headache sufferers. Am J Psychiatry 147:303-8

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