Subcortical brain regions have been shown to have direct projections to the marginal zone (lamina 1) and substantia gelatinosa (lamina 2). These projections presumably play a role in the modulation of nociceptive input, which is known to relay in these laminae. The current proposal is to study the extent and influence of newly discovered direction projections from the cerebral cortex to spinal cord laminae 1 and 2. These initial studies will use single axon recording and intraaxonal injection of HRP to label physiologically identified corticospinal axons and their spinal terminations for both light and EM analyses. The results will provide information on the function of direct projections from the cerebral cortex to the superficial dorsal horn.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020339-02
Application #
3400660
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1984-07-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599