Procedures for Penetrating the Blood-Brain Barrier

Shashoua, Victor E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 3R01NS020571-03S1
• Application #: 3400977
• Study Section: Neurology A Study Section (NEUA)
• Project Start: 1984-12-01
• Project End: 1988-02-29
• Budget Start: 1987-12-01
• Budget End: 1988-02-29
• Support Year: 3
• Fiscal Year: 1988

Institution

• Name: Mc Lean Hospital (Belmont, MA)
• City: Belmont
• State: MA
• Country: United States
• Zip Code: 02478

Publications

Jacob, J N; Hesse, G W; Shashoua, V E (1990) Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor gamma-vinyl-GABA. J Med Chem 33:733-6

Backus, L I; Stellar, J R; Jacob, J et al. (1988) Novel GABA agonists depress the reward effect of lateral hypothalamic stimulation in rats. Pharmacol Biochem Behav 30:657-63

Hesse, G W; Jacob, J N; Shashoua, V E (1988) Uptake in brain and neurophysiological activity of two lipid esters of gamma-aminobutyric acid. Neuropharmacology 27:637-40

Jacob, J N; Hesse, G W; Shashoua, V E (1987) gamma-Aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 glyceryl lipid esters of GABA with varying degree of unsaturation. J Med Chem 30:1573-6