Abstract

The objective of this research program is to understand the neurobiological mechanisms underlying the developmental changes associated with early experience. We will test the hypothesis that an increased number and/or size of a particular class of cells mediates the observed structural and functional changes consequent to early experience. We will therefore determine whether the number of cells and/or the size of their dendritic arbors underlies this form of plasticity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS021484-04
Application #
3402628
Study Section
Biopsychology Study Section (BPO)
Project Start
1984-12-01
Project End
1991-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Sullivan, R M; Wilson, D A; Leon, M (1989) Norepinephrine and learning-induced plasticity in infant rat olfactory system. J Neurosci 9:3998-4006
Gomez-Pinilla, F; Guthrie, K M; Leon, M et al. (1989) NGF receptor increase in the olfactory bulb of the rat after early odor deprivation. Brain Res Dev Brain Res 48:161-5
Guthrie, K M; Leon, M (1989) Induction of tyrosine hydroxylase expression in rat forebrain neurons. Brain Res 497:117-31
Lincoln, J; Coopersmith, R; Harris, E W et al. (1988) NMDA receptor activation and early olfactory learning. Brain Res 467:309-12
Do, J T; Sullivan, R M; Leon, M (1988) Behavioral and neural correlates of postnatal olfactory conditioning: II. Respiration during conditioning. Dev Psychobiol 21:591-600
Sullivan, R M; Wilson, D A; Leon, M (1988) Physical stimulation reduces the brain temperature of infant rats. Dev Psychobiol 21:237-50
Sullivan, R M; Wilson, D A; Kim, M H et al. (1988) Behavioral and neural correlates of postnatal olfactory conditioning: I. Effect of respiration on conditioned neural responses. Physiol Behav 44:85-90
Coopersmith, R; Leon, M (1987) Glycogen phosphorylase activity in the olfactory bulb of the young rat. J Comp Neurol 261:148-54
Sullivan, R M; Leon, M (1987) One-trial olfactory learning enhances olfactory bulb responses to an appetitive conditioned odor in 7-day-old rats. Brain Res 432:307-11
Woo, C C; Coopersmith, R; Leon, M (1987) Localized changes in olfactory bulb morphology associated with early olfactory learning. J Comp Neurol 263:113-25

Showing the most recent 10 out of 20 publications