The specific goals of the current proposal are to: (1) examine the contributions of working memory (rehearsal maintenance), focused and divided attention, and motivational factors to the recent memory deficits of MS patients, (2) determine if quantitative measurements of MR relaxation parameters (T1, T2 and proton density) are effective in predicting cognitive and affective disturbance, particularly when compared to quantitative MRI indices of lesion area and location, ventricular size, and size of the corpus callosum, (3) study the long-term changes in cognition, affect, neurological status, and neuroimaging of a large, representative sample of MS patients using a prospective, longitudinal research design, and (4) investigate the long-term, neuropsychological significance of leuko-araiosis in otherwise healthy individual using a prospective, longitudinal design. By the end of the proposed project, 100 MS patients and 100 demographically-matched, healthy controls will have undergone three 2-day outpatient evaluations separated by 3 year retest intervals. At each evaluation, subjects will be administered a comprehensive battery of cognitive and affective psychometric tests, and will undergo a neurologic examination (including measures of disability), MRI, an audiological examination, a videotaped psychosocial interview, and an in-home evaluation of activities of daily living.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022128-07
Application #
3404156
Study Section
Neurology A Study Section (NEUA)
Project Start
1985-12-01
Project End
1993-11-30
Budget Start
1991-12-01
Budget End
1993-11-30
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Schwartz, C E; Foley, F W; Rao, S M et al. (1999) Stress and course of disease in multiple sclerosis. Behav Med 25:110-6
Nyenhuis, D L; Luchetta, T; Yamamoto, C et al. (1998) The development, standardization, and initial validation of the Chicago Multiscale Depression Inventory. J Pers Assess 70:386-401
Arnett, P A; Rao, S M; Grafman, J et al. (1997) Executive functions in multiple sclerosis: an analysis of temporal ordering, semantic encoding, and planning abilities. Neuropsychology 11:535-44
Rao, S M (1996) White matter disease and dementia. Brain Cogn 31:250-68
Rao, S M (1995) Neuropsychology of multiple sclerosis. Curr Opin Neurol 8:216-20
Nyenhuis, D L; Rao, S M; Zajecka, J M et al. (1995) Mood disturbance versus other symptoms of depression in multiple sclerosis. J Int Neuropsychol Soc 1:291-6
Arnett, P A; Rao, S M; Bernardin, L et al. (1994) Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology 44:420-5
Rao, S M; Huber, S J; Bornstein, R A (1992) Emotional changes with multiple sclerosis and Parkinson's disease. J Consult Clin Psychol 60:369-78
Haughton, V M; Yetkin, F Z; Rao, S M et al. (1992) Quantitative MR in the diagnosis of multiple sclerosis. Magn Reson Med 26:71-8
Rao, S M; Leo, G J; Bernardin, L et al. (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41:685-91

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