The sensorimotor control of human posture will be investigated theoretically, in close collaboration with experimental studies and clinical programs. The proposed studies continue ongoing explorations of simple ways the nervous system can control posture by stored, habitual responses, using little on-line calculation. This proposal is divided into three major projects: The first study will be on postural mechanics as controlled by muscle burst patterns or synergies. We have described the structure and mechanics of these synergies and their mixtures in the quasi-static case for two dimensions. This study will expand the analysis to non-static cases and to a third dimension, allowing the analysis to be applied to more patient groups and more natural situations. The mathematical approach will allow a generalization to other movements, such as arm and head movements, and a statement of the types of movement trajectories that can be controlled by analogous combinations of muscle burst patterns. The second study will describe the coordination of orientation senses, visual, vestibular, and tactile, in controlling movements. Sensory feedback from the three different orientation senses must be properly blended to give an accurate representation of movement. We will investigate how this is done by both normal subjects and groups of vestibular patients, and how sensory deficits in vestibular patients affect their movements. The third project is to find constraints on a combined sensorimotor control system which allows both proper interpretation of sensory inputs and appropriate mechanical interaction of muscle forces with body mechanics and the support surface. This project will use the results of the previous two.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023209-03
Application #
3406427
Study Section
Hearing Research Study Section (HAR)
Project Start
1986-03-01
Project End
1989-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Good Samaritan Hosp & Medical Center(Prtlnd,OR)
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97210
Holly, J E; McCollum, G (1996) The shape of self-motion perception--I. Equivalence classification for sustained motions. Neuroscience 70:461-86
Roberts, P D; McCollum, G (1996) Dynamics of the sit-to-stand movement. Biol Cybern 74:147-57
Holly, J E; McCollum, G (1996) The shape of self-motion perception--II. framework and principles for simple and complex motion. Neuroscience 70:487-513
McCollum, G; Shupert, C L; Nashner, L M (1996) Organizing sensory information for postural control in altered sensory environments. J Theor Biol 180:257-70
McCollum, G; Holroyd, C; Castelfranco, A M (1995) Forms of early walking. J Theor Biol 176:373-90
McCollum, G (1994) Navigating a set of discrete regions in body position space. J Theor Biol 167:263-71
Castelfranco, A M; Robertson, L T; McCollum, G (1994) Detail, proportion, and foci among face receptive fields of climbing fiber responses in the cat cerebellum. Somatosens Mot Res 11:27-46
McCollum, G (1993) Reciprocal inhibition, synergies, and movements. J Theor Biol 165:291-311
McCollum, G (1992) Rules of combination that generate climbing fiber tactile receptive fields. Neuroscience 50:707-25
Robertson, L T; McCollum, G (1991) Stimulus classification by ensembles of climbing fiber receptive fields. Trends Neurosci 14:248-54

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