Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023321-02
Application #
3406627
Study Section
(DABA)
Project Start
1986-02-01
Project End
1989-01-31
Budget Start
1987-02-01
Budget End
1988-01-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
During, M J; Craig, J S; Hernandez, T D et al. (1992) Effect of amygdala kindling on the in vivo release of GABA and 5-HT in the dorsal raphe nucleus in freely moving rats. Brain Res 584:36-44
Hernandez, T D; Gallager, D W (1992) Development of long-term subsensitivity to GABA in dorsal raphe neurons of amygdala-kindled rats. Brain Res 582:221-5
Marley, R J; Heninger, C; Hernandez, T D et al. (1991) Chronic administration of beta-carboline-3-carboxylic acid methylamide by continuous intraventricular infusion increases GABAergic function. Neuropharmacology 30:245-51
Gallager, D W; Tallman, J F (1990) Relationship of GABAa receptor heterogeneity to regional differences in drug response. Neurochem Res 15:113-8
Hernandez, T D; Rosen, J B; Gallager, D W (1990) Long-term changes in sensitivity to GABA in dorsal raphe neurons following amygdala kindling. Brain Res 517:294-300
Hernandez, T D; Heninger, C; Wilson, M A et al. (1989) Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure. Eur J Pharmacol 170:145-55
Wilson, M A; Gallager, D W (1989) Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. II. Modulation of firing rate. J Pharmacol Exp Ther 248:886-91
Wilson, M A; Gallager, D W (1989) Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. I. Modulation of gamma-aminobutyric acid sensitivity. J Pharmacol Exp Ther 248:879-85
Heninger, C; Gallager, D W (1988) Altered gamma-aminobutyric acid/benzodiazepine interaction after chronic diazepam exposure. Neuropharmacology 27:1073-6
Davis, M; Gallager, D W (1988) Continuous slow release of low levels of diazepam produces tolerance to its depressant and anxiolytic effects on the startle reflex. Eur J Pharmacol 150:23-33

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