Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS023515-02
Application #
3407107
Study Section
Toxicology Study Section (TOX)
Project Start
1987-11-01
Project End
1990-06-30
Budget Start
1987-11-01
Budget End
1988-06-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Pharmacy
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Klaidman, L K; Adams Jr, J D; Leung, A C et al. (1993) Redox cycling of MPP+: evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase. Free Radic Biol Med 15:169-79
Adams, J D; Pickford, M S; Wong, C G (1992) The acute retinal histopathology of MPTP. Neurotoxicology 13:541-49
Adams Jr, J D; Klaidman, L K; Odunze, I N et al. (1991) Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Mol Chem Neuropathol 14:213-26
Adams Jr, J D; Odunze, I N (1991) Oxygen free radicals and Parkinson's disease. Free Radic Biol Med 10:161-9
Adams Jr, J D; Klaidman, L K; Odunze, I N et al. (1991) Effects of MPTP on the cerebrovasculature. Int J Dev Neurosci 9:155-9
Adams Jr, J D; Odunze, I N; Sevanian, A (1990) Induction by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of lipid peroxidation in vivo in vitamin E deficient mice. Biochem Pharmacol 39:R5-8
LeBel, C P; Odunze, I N; Adams Jr, J D et al. (1989) Perturbations in cerebral oxygen radical formation and membrane order following vitamin E deficiency. Biochem Biophys Res Commun 163:860-6
Adams Jr, J D; Kalivas, P W; Miller, C A (1989) The acute histopathology of MPTP in the mouse CNS. Brain Res Bull 23:1-17